5. A SCOPING REVIEW: COMPARISON OF COAGULATION PARAMETERS RESULTS IN DECEASED AND RECOVERED COVID-19 PATIENTS
Main Article Content
Abstract
Objective: Compare coagulation markers between deceased and recovered COVID-19 patients.
Methods: A search of PubMed was conducted to identify peer-reviewed articles published between January 1, 2022, and April 1, 2024. Articles were selected based on predefined inclusion and exclusion criteria. Data extraction focused on coagulation parameters, including platelet count, fibrinogen (Fib), D-Dimer, prothrombin time (PT), and activated partial thromboplastin time (APTT) across six selected studies involving a total of 7,052 patients.
Results: The findings indicated that recovered patients had significantly higher platelet counts compared to deceased patients (p < 0.05). D-Dimer and Fib levels were lower in recovered patients, while PT results were significantly prolonged in deceased individuals (p < 0.05). APTT results showed variability, with some studies reporting higher levels in deceased patients, while others indicated longer APTT in recovered patients, remaining within normal ranges.
Conclusion: Coagulation markers exhibit significant differences between deceased and recovered COVID-19 patients, suggesting their potential utility in predicting disease severity and guiding clinical management.
Article Details
Keywords
coagulation parameters, deceased COVID-19 patients, recovered COVID-19 patients
References
[2] Quintana-Díaz M A-EE, Ramírez-Cervantes KL, Olivan-Blázquez B, Juárez-Vela R, Gea-Caballero V. Coagulation Parameters: An Efficient Measure for Predicting the Prognosis and Clinical Management of Patients with COVID-19. J Clin Med. 2020;9(11):3482.
[3] Celikkol A DM, Guzel EC, Erdal B, Yilmaz A. A novel combined index of D-dimer, fibrinogen, albumin, and platelet (FDAPR) as mortality predictor of COVID-19. Niger J Clin Pract. 2022;25(9):1418-23.
[4] Blomme S SL, Van Ranst M, Boeckx N, Van Laer C. The influence of COVID-19 on routine hematological parameters of hospitalized patients. Acta Clin Belg. 2022;77(2):241-6.
[5] Peng F YQ, Zhang Q, Deng J, Li C, Xu M, Wu C, Zhong Y, Wu S. Performance of D-dimer to lymphocyte ratio in predicting the mortality of COVID-19 patients. Front Cell Infect Microbiol. 2022;12:1053039.
[6] Tahir Huyut M HZ, İlkbahar F, Mertoğlu C. What is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality? Int Immunopharmacol. 2022;105:108542.
[7] Ahirwar AK TR, Sakarde A, Rathod BD, Jha PK, Kumawat R, Gopal N. The study of serum hsCRP, ferritin, IL-6 and plasma D-dimer in COVID-19: a retrospective study. Horm Mol Biol Clin Investig. 2022;43(3):337-44.
[8] Ali AM RH, Fatah MH, Noori CM, Ali KM, Tawfeeq HM. Serum troponin, D-dimer, and CRP level in severe coronavirus (COVID-19) patients. Immun Inflamm Dis. 2022;10(3):e582.