CARBAPENEM RESISTANT ENTEROBACTERIACEA CARRIAGE AND TRANSMISSION AMONG SICK NEWBORN ADMITTED TO NGHE AN OBSTETRICS AND PEDIATRICS HOSPITAL, 2022
Main Article Content
Abstract
Objectives: To estimate the distribution, transmission rate, and the risk of transmission of
Carbapenem-resistant Enterobacteriaceae (CRE) isolated from newborns patients admitted to the
Nghe An Obstetrics and Pediatrics Hospital between June 2022 and July 2022.
Methods: A cohort study with screening for colonization with CRE was conducted on 156
newborns under 28 days old admitted to neonatal department, Nghe An Obstetrics and Pediatrics
Hospital between June 2022 and July 2022. CRE colonization was determined by culturing of
fecal specimens on Carba-smart medium for CRE. Risk factors for CRE transmission were
evaluated.
Results: The prevalence of CRE infections was 3.2% upon admission and 53.2% at discharge.
Fifty percent of patients with negative screening results for CRE were infected during the
hospitalized days. K. Pneumoniae agent was the leading cause of transmission. Sex, gestational
age, birth weight, respiratory failure, mechanical ventilation, and Oxygen inhalation are factors
associated with CRE transmission.
Conclusions: The prevalence of CRE infections increased during the hospitalized period.
K.Pneumoniae agent was the leading cause of transmission. Gestational age, sex, birth weight,
respiratory failure, mechanical ventilation, and oxygen inhalation
Article Details
Keywords
CRE ( ), neonate, transmission, carrier.
References
Thị Bích Ngọc, Tỷ lệ bệnh nhân mang vi khuẩn
Gramâm kháng carbapenem tại Bệnh viện Nhi
Trung ương, Tạp chí Y Dược lâm sàng 108, tập
12, số đặc biệt 10, 2017.
2. Lê Kiến Ngãi, Trần Văn Hường, Mức độ
lây truyền và yếu tố liên quan ở trẻ sơ sinh
mang vi khuẩn Gram âm kháng Carbapenem tại
Bệnh viện Nhi Trung ương. Tạp chí Nhi khoa
tập 12, số 2, 2019.
3. Grundmann H, “Occurrence of
carbapenemase-producing Klebsiella
pneumoniae and Escherichia coli in the
European survey of carbapenemase-producing
Enterobacteriaceae (EuSCAPE): a prospective,
multinational study,” Lancet Infect. Dis., vol.
17, no. 2, pp. 153–163.
4. Nordmann P, Cuzon G, Naas T, “The real
threat of Klebsiella pneumoniae
carbapenemase-producing bacteria,” Lancet
Infect. Dis., vol. 9, no. 4, pp. 228–236, 2009.
5. Schechner V, Kotlovsky T, Kazma M et
al, Asymptomatic rectal carriage of blaKPC
producing carbapenem-resistant
Enterobacteriaceae: who is prone to become
clinically infected? Clinical microbiology and
infection : the official publication of the
European Society of Clinical Microbiology and
Infectious Diseases.19(5):451-6.
doi:10.1111/j.1469-0691.2012.03888, 2013.
6. Lin BY, Liu JT, Jin FL, Risk factors for
the colonization or infection of carbapenemresistant Enterobacteriaceae in children: a Meta
analysis. Zhongguo dang dai er ke za zhi =
Chinese journal of contemporary
pediatrics.24(1):96-10.
doi:10.7499/j.issn.1008-8830.2109025, 2022.