Article Sidebar

Published: 2022-04-06
Abstract Views: 240
DOI: https://doi.org/10.52163/yhc.v63i2.315
Issue
Vol. 63 No. 2 (2022)
Section
Articles
How to Cite
Kiên, T. B. ., Tuyết, D. Ánh ., Dương, N. T. ., & Đông, N. T. . (2022). Assessment on toxicity of fatty oil extracted from perilla seeds. Vietnam Journal of Community Medicine, 63(2). https://doi.org/10.52163/yhc.v63i2.315

Assessment on toxicity of fatty oil extracted from perilla seeds

Tran Ba Kien1, Duong Anh Tuyet2, Nguyen Thuy Duong2, Nguyen Thi Dong3
1 Hai Duong Central College of Pharmacy
2 Hanoi University of Pharmacy
3 Administration of science technology and training

Main Article Content

Abstract

Fatty oil extracted from perilla seeds contains unsaturated fatty acids linolenic acid and linoleic acid which have good effects in lowering blood lipids. The study was conducted to determine the toxicity of perilla seed oil as a basis for developing production of perilla seed fatty oil into a safe product, supporting the treatment of dyslipidemia. The test results showed that the test product prepared from fatty oil extracted from perilla seeds at a dose of 40mL/kg (Acid linoleic 58,48%, acid linolenic 19,27%) – the highest dose that could be given to rats through a curved needle - did not show acute toxicity. When administered in repeated dose for 28 days, perilla seed oil showed no toxicity in rabbits.

Article Details

Keywords

Acute toxicity, semi-permanent toxicity, perilla seed oil.

References

1. Cardiovascular diseases, https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds), Accessed 20 June 2021
2. To MT, Tram VT, Academic Pharmacology 2. Medical Publishing House, 2018.
3. Kyeong RL, Kyung HK, Jung BK, et al., High accumulation of γ-linolenic acid and Stearidonic acid in transgenic Perilla seeds. BMC Plant Biology, 2019; 19: 120.
4. Kim SR, Je J, Jeong K, et al., Perilla Oil Decreases Aortic and Hepatic Lipid Accumulation by Modulating Lipogenesis and Lipolysis in High-Fat Diet-Fed Mice, Journal of Medicinal Food 2018; 22(1), 14-21.
5. Guidelines for preclinical and clinical trials of traditional and herbal medicines - Ministry of Health, https://thuvienphapluat.vn/van-ban/The-thao-Y-te/Quyet-dinh-141-QD-K2DT-2015-Huong-dan-thu-nghiem-tien-lam-sang-lam-sang-thuoc-dong-y-414589.aspx. Accessed 14 March 2021.
6. OECD, Test Guidelines for Chemicals, OECD, 2021; Section 4, Test No. 407,420,423,425.
7. Shayne CG., Drug safetey evalution, Wiley, 2002.
8. Dam DT, How to express dosage of substances extracted from medicinal herbs. Medical Publishing House 2015; p. 565-568.
9. Zhang H, Guan J, Tian Y et al., Acute and sub-chronic 90-day oral toxicity study of Perilla seed oil in rodents and Beagle dogs, Regulatory Toxicology and Pharmacology, 2019; 103: 229-236.
10. Yang Z, Ren T, Lu D et al., Evaluating the safety of phytosterols removed perilla seed oil-based lipid emulsion, Taylor & Francis, 2016; 13(10): 1345-1356.