33. ĐẶC ĐIỂM MÔ BỆNH HỌC, ĐỘ MÔ HỌC VÀ GIAI ĐOẠN pTMN CỦA UNG THƯ BIỂU MÔ TUYẾN PHỔI ĐƯỢC PHẪU THUẬT TẠI BỆNH VIỆN PHỔI TRUNG ƯƠNG NĂM 2022

Abstract

Objective: Describe the histopathological characteristics, histological grade, and Ptnm staging of operated lung adenocarcinoma based on the guidelines of the WHO 2021 classification.

Methods: Cross-sectional descriptive study on patients with operated lung adenocarcinoma (≥18 years old) admitted to the National Lung Hospital from January to December 2022. We collected data on clinical and histopathological characteristics, pTNM stage, histological grade are new points in the 2021 histopathological classification.

Results: 186 patients with operated lung adenocarcinoma were collected and evaluated for target characteristics with a predominance in men (54.8%), smokers (58.1 %); age 60 or older (56.5%) with the largest number being in the 60-69 age group; Stage IB accounts for the highest rate. The most common histopathological type is invasive non-mucinous adenocarcinoma (97.8%), with the dominant acinar eubtype accounting for the highest proportion; histological grade III is the most common with a rate of 51.1%, predominantly in patients over 60 years old, smokers (p < 0.05), stages II, IIIA; The STAS pattern (tumor spread in the air space) appears in 25.8% of cases, accounting for a higher proportion under the dominant micropapillary type and histological grade III (p<0.05) and stage II.

Conclusion: Lung cancer is mainly operated on in men, smokers, from 60 years old. In terms of histopathology, invasive non-mucinous adenocarcinoma accounts for the majority with a high prevalence of cystic cluster type. Most importantly, assessment of histological grade has negative prognostic factors such as poorly differentiated histological grade (grade III), micropapillary morphology and STAS model, stages IIB, IIIA, which are new updates in the classification. WHO 2021 surgical lung cancer tissue types. This is the basis for developing research to monitor and evaluate patients after surgery, and provide adjunctive treatment options for patients.