16. RESULTS OF EDUCATIONAL INTERVENTION IN CONTROL OF HYPERURICEMIA IN END-STAGE RENAL DISEASE PATIENTS ON HEMODIALYSIS AT CA MAU GENERAL HOSPITAL

Nguyen Nhu Nghia1, Tran Thi To Quyen2, Mai Huynh Ngoc Tan1
1 Can Tho University of Medicine and Pharmacy
2 Ca Mau General Hospital

Main Article Content

Abstract

Objective: To evaluate the results of educational intervention in controlling hyperuricemia in endstage renal disease (ESRD) patients on hemodialysis.


Subject and method: A longitudinal follow-up study of 211 ESRD patients undergoing hemodialysis at Ca Mau General Hospital from July 2022 to April 2023.


Results: 211 patients participated in the study, mean age was 49.54±12.82. There were 88.2% of ESRD patients with hyperuricemia. After 3 months of educational intervention, 26.4% of patients achieved their serum UA target; after 6 months, nearly 2/3 of the patients achieved the treatment goal, the effectiveness index increased from 26.4% to 71.4%, p = 0.001. The mean UA concentration before intervention was 8.46±1.4 mg/dL, after 3 months was 7.35±1.79mg/dL and after 6 months was 5.17±2.34mg/dL, p= 0.001. Female gender and the habit of regularly eating purine-rich foods were independently associated with the rate of not reaching UA targets after educational intervention.


Conclusion: The rate of hyperuricemia in ESRD patients was very high, 88.2%. Educational intervention with lifestyle changes in patients undergoing hemodialysis was effective in controlling serum UA.

Article Details

References

[1] Davide G, Livia F, Giovambattista D et al.,
Chronic hyperuricemia, uric acid deposit and
cardiovascular risk, Curr Pharm Des, 19(13),
2013, 2432-2438.
[2] Eghlim N, Arezoo K, Behzad E et al., The
relationship between dialysis adequacy and serum
uric acid in dialysis patients; a cross-sectional
multi-center study in Iranian hemodialysis
centers, J Renal Inj Prev, 6(2, 2017, 142-147.
[3] Nguyễn Văn Tuấn, Khảo sát nồng độ acid uric
huyết thanh ở bệnh nhân bệnh thận mạn giai
đoạn cuối, Tạp chí Y học Việt Nam, 504(2),
2021, 147-151.
[4] Nguyễn Vĩnh Ngọc, Bệnh Gút; Bệnh học cơ
xương khớp nội khoa, Nhà xuất bản Giáo dục
Việt Nam, Hà Nội, 2009, trang 187-210.
[5] Kiyoko K, Yasuo A, Tomoko F et al., Total126
purine and purine base content of common
foodstuffs for facilitating nutritional therapy
for gout and hyperuricemia. Biol. Pharm. Bull,
37(5), 2014, 709–721.
[6] Adam MZ, Juan JC, Melanie W et al., Serum Uric
Acid and Mortality Risk Among Hemodialysis
Patients, Kidney International Reports, 5: 1196–
1206, 2020.
[7] Farya M, Sarfraz A, Muhammad YY et al.,
Prevalence of Hyperuricemia in Thrice Weekly
Maintenance Hemodialysis Patients, Pak J
Kidney Dis, 6(3), 2022, 10-14.
[8] Trịnh Kiến Trung, Nghiên cứu nồng độ acid uric
máu, bệnh gút và hội chứng chuyển hóa ở người
từ 40 tuổi trở lên tại thành phố Cần Thơ, Luận án
Tiến sĩ y học, Học viện Quân Y, Hà Nội, 2015.