25. THE SUSCEPTIBILITY OF STREPTOCOCCUS PNEUMONIAE TO ANTIBIOTICS AMONG CHILDREN TREATED AT THE NATIONAL CHILDREN’S HOSPITAL, 2020
Main Article Content
Abstract
Objectives: Streptococcus pneumoniae causes severe diseases with a high mortality rate. The study
aims to determine the susceptibility of Streptococcus pneumoniae to antibiotics among children aged
< 5 years old at the National Children’s Hospital to find the most effective treatment.
Study methods: The study was conducted in the laboratory with a descriptive research design.
Results: Streptococcus was resistant to macrolides (> 95%), cotrimoxazole (90%), and clindamycin
(95.3%). Multiple antibiotic resistance Streptococcus accounted for 64%. In addition, 100% of
Streptococcus were sensitive to rifampicin, linezolid and vancomycin, followed by amoxicillin
(MIC90 = 2 µg/ml) at 95%, ceftriaxone (MIC90 = 4 µg/ml) at 61.1%, cefotaxime (MIC90 = 4 µg/ml) at
57.4%, and penicillin G (MIC90=4 µg/ml) at 43.9%.
Conclusions: Streptococcus was resistant to penicillins, cephalosporins, sulphonamides, and
macrolides. It was still sensitive to rifampin, glycopeptides, oxazolidinones, and quinolones.
Therefore, the treatment of Streptococcus pneumoniae should be based on its antibiotic resistance
patterns to find the most sensitive antibiotic.
Article Details
Keywords
Streptococcus, pneumoniae, children,MIC: minimum Inhibitory Concentration.
References
of Streptococcus pneumoniae and Haemophilus
influenzae type b disease in children in India:
modelled estimates for 2000-15., The lancet Glob
Health, Vol.7(6), pp.735-747, 2018.
[2] Viện Sốt rét - Ký sinh trùng - Côn trùng Trung
ương, Phương pháp nghiên cứu khoa học, Sách
đào tạo sau đại học, Nhà Xuất bản Y học, 2018.
[3] Song JH, Jung SI, Ko KS et al., High prevalence
of antimicrobial resistance among clinical
Streptococcus pneumoniae isolates in Asia (an
ANSORP study). Antimicrob Agents Chemother,
48 (6), 2101-2107, 2004.
[4] Van PH, Binh PT, Minh NH et al., Results from
the Survey of Antibiotic Resistance (SOAR)
2009-11 in Vietnam. J Antimicrob Chemother, 71
Suppl 1 (Suppl 1), i93-102, 2016.
[5] Torumkuney D, Van PH, Thinh LQ et al., Results
from the Survey of Antibiotic Resistance (SOAR)
2016-18 in Vietnam, Cambodia, Singapore and the
Philippines: data based on CLSI, EUCAST (dosespecific)
and pharmacokinetic/pharmacodynamic
(PK/PD) breakpoints. J Antimicrob Chemother,
75 (Suppl 1), i19-i42, 2020.
[6] Hoa NQ, Trung NV, Larsson M et al., Decreased
Streptococcus pneumoniae susceptibility to oral
antibiotics among children in rural Vietnam: a
community study. BMC Infect Dis, 10 (85),
1-11, 2010.
[7] Larsson M, Nguyen HQ, Olson L et al.,
Multidrug resistance in Streptococcus pneumoniae
among children in rural Vietnam more than
doubled from 1999 to 2014. Acta Paediatr, 111
(6), 1916-1923, 2021.
[8] Wang CY, Chen YH, Fang C et al., Antibiotic
resistance profiles and multidrug resistance
patterns of Streptococcus pneumoniae in
pediatrics: A multicenter retrospective study in
mainland China. Medicine (Baltimore), 98(24),
e15942, 2019.
[9] Kim SH, Song JH, Chung DR et al., Changing
trends in antimicrobial resistance and serotypes
of Streptococcus pneumoniae isolates in Asian
countries: an Asian Network for Surveillance
of Resistant Pathogens (ANSORP) study.
Antimicrob Agents Chemother, 56 (3), 1418-
1426, 2012.
[10] Batah Jameed and Vanron Emmanuenlle, Rappor
dactivite 2020, Epidemiologie 2018 -2019, Centre
National de Reference des Pneumocoques, Crteil.
pp1-80, 2020.