9. STUDY ON EFFECTIVENESS OF ANTI-INFLAMMATORY, ANTI-MICROBIAL OF COLD PLASMA IN PATIENTS WITH INFECTIOUS WOUND
Main Article Content
Abstract
Objective: This study aims to assess the safety and effectiveness of using anti-inflammatory and
bactericidal plasma generated from the PlasmaMed machine manufactured in Vietnam for treating
infected wounds.
Methods: This study was a controlled clinical trial involving 31 patients with infected wounds.
Of the 31 patients, 20 had two similar wound areas, with one area treated with plasma irradiation
while the other received routine dressing changes and served as the control group. The remaining 11
patients had only one wound area treated with plasma irradiation. The efficacy of the treatment was
measured using various indicators, including C-reactive protein (CRP), procalcitonin (PCT), and
bacterial concentration at the wound site.
Results: The study showed a significant decrease in CRP and PCT levels immediately after the first
and fifth day of cold plasma irradiation. Additionally, the concentration of bacteria on the wound
surface was significantly reduced after the first plasma irradiation. By day 5, most of the patients’
wounds were completely clean, with positive changes observed, such as fast atrophy, reduced
exudation, healing of wound edges, and tissue growth, resulting in a uniform coloration of the overall
wound surface.
Conclusion: Based on the study results, it can be concluded that cold plasma generated from the
PlasmaMed machine has anti-inflammatory and bactericidal effects that can prevent infection in soft
wounds immediately after the first exposure and up to five days after treatment.
Article Details
Keywords
PlasmaMed, cold plasma, technology, wound care.
References
tại các cơ sở ngoại khoa”. Tạp chí Y học Việt
Nam, (5), tr. 27 – 31, 1991.
[2] Tian Y et al., “Inactivation of Staphylococcus
aureus and Enterococcus faecalis by a directcurrent,
cold atmospheric-pressure air plasma
microjet”, J Biomed Res. 24(4), 264-9, 2010.
[3] Kong MG et al., “Plasma medicine: an
introductory review”, New Journal of Physics.
11(11), 115012, 2009.
[4] Boekema BKHL, Vlig M, Guijt D et al., A new
flexible DBD device for treating infected wounds:
in vitro and ex vivo evaluation and comparison
with a RF argon plasma jet. J Phys D Appl Phys.
2016;49:044001, 2016.
[5] Boekema BKHL, Hofmann SS, van Ham BJT et
al., Antibacterial plasma at safe levels for skin
cells. J Phys D Appl Phys. 46:422001, 2013.
[6] Morfill G, Shimizu T, Steffes B et al.,
Nosocomical infections-a new approach towards
preventive medicine using plasmas. New J Phys.
2009;11:115019, 2009.
[7] Li YF, Taylor D, Zimmermann JL, In vivo skin
treatment using two portable plasma devices:
comparison of a direct and an indirect cold
atmospheric plasma treatment. Clin Plasma Med.
2013;1:35–9, 2013.
[8] Do Hoang Tung, Cold atmospheric pressure
gliding arc plasma jet for decontamination,
Communications in Physics, Vol. 24, No. 3S2,
pp. 129-134, 2014.
[9] Isbary G, Morfill G, Schmidt HU et al., A first
prospective randomized controlled trial to
decrease bacterial load using cold atmospheric
argon plasma on chronic wounds in patients, Br J
Dermatol 163(1), 78-82, 2010.