27. VALUE OF CFFDNA CONCENTRATIONS IN NIPT FOR PRENATAL SCREENING OF DOWN SYNDROME
Main Article Content
Abstract
Research objectives: Analyzing the value of cffDNA levels in non-invasive prenatal testing (NIPT)
for Down syndrome.
Research method and duration: A retrospective cross-sectional descriptive study on 17,451
pregnant women who received NIPT from October 2020 to July 2022.
Results and conclusions: There was a positive correlation between the cffDNA concentration and the
gestational week, but negatively correlated with the age of the pregnant woman in the study. Among
the group of pregnant women with positive NIPT results, there was a strong positive correlation
between the cffDNA concentration and z-score.
Article Details
Keywords
NIPT, cffDNA, trisomy 21.
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amniocentesis and chorionic villus sampling: a
systematic review and meta-analysis. Ultrasound
Obstet Gynecol, 45, 16-26, 2015.
[2] Hoàng Hải Yến và cộng sự, Nghiên cứu giá trị
của phương pháp giải trình tự gen thế hệ mới phát
hiện lệch bội nhiễm sắc thể thai bằng DNA thai tự
do trong máu mẹ, 56-129, 2020.
[3] Hoàng Hải Yến và cộng sự, Bước đầu đánh giá các
yếu tố ảnh hưởng đến DNA thai tự do trong huyết
tương mẹ. Tạp chí Phụ sản, 17(02), 11-17, 2019.
[4] Yuan T, Linlin Z, Weifang T et al., Analysis of
the accuracy of z-scores of noninvasive prenatal
testing for fetal trisomy 13,18 and 21 that employs
the ion proton semiconduction sequencing
platform. Molecular Cytogenetics, 11, 49.
[5] Dar P, Curnow KJ, Gross SJ et al., Clinical
experience and follow-up with large SCAle
single-nucleotide polymorphism-based
noninvasive prenatal aneuploidy testing. Am J
Obstet Gynecol, 211, 527.e1-17, 2014.
[6] Pergament E, Cuckle H, Zimmermann B et
al., Single-nucleotide polymorphism-based
noninvasive prenatal screening in a high-risk
and low-risk cohort. Obstet Gynecol, 124, 210-8,
2014.
[7] Eric W, Annette B, Craig S et al., Gestational
age and maternal weight effects on fetal cell-free
DNA in maternal plasma. Prenat Diagn, 33, 662-
666, 2013.
[8] Zhou Y, Zhu Z, Gao Y et al., Effects of Maternal
and Fetal Characteristics on Cell-Free Fetal
DNA Fraction in Maternal Plasma. Reproductive
Sciences, 22(11), 1429-35, 2015.