ĐẶC ĐIỂM TỔN THƯƠNG GAN DO CYTOMEGALO VIRUS Ở TRẺ EM TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Objectives: To describe the clinical and subclinical characteristics of liver damage in children
due to Cytomegalovirus infection and comment on the results of treatment of liver damage in
children due to Cytomegalovirus infection at Central Children's Hospital.
Research object and method: Retrospective study - prospective study, describing over 70
pediatric patients 1-12 months diagnosed with liver damage caused by Cytomegalovirus and
treated at Central Children's Hospital in the period from 01/01/2020 – 30/06/2022.
Result: 70 patients with CMV liver injury were followed for 6 months with the following
ratios: Mean age of patients was 2.17 ± 1.77 months, and men accounted for 84.3%, jaundice
85.7%, enlarged liver 67.1%, silver stool 54.3%, dark urine 47.1%, subcutaneous hemorrhage
5.7%. Alanine aminotransferase and aspartate aminotransferase both increased in all patients.
Billirubin directly increased by 91%. 50/70 (71.4%) patients were treated with ganciclovir. The
improvement in liver injury was 87.1% and no complications accounted for 87.1%.
Conclusion: Most patients have good results after treatment. However, it is necessary to detect
and treat in time to limit the severe damage caused by CMV.