THE DISTRIBUTION OF PNEUMOCOCCAL SEROTYPES CAUSES PNEUMONIA IN CHILDREN UNDER 5 YEARS OF AGE IN NGHE AN
Main Article Content
Abstract
Objective: To determine the distribution of pneumococcal serotypes in children under 5 years
old in Nghe An.
Methods: In this cross-sectional descriptive study, 160 nasalpharyngeal samples positive with
S. pneumonia were collected from children under five years old in Nghe An Obstetrics and
Gynecology Hospital from August 2020 to August 2022.
Result: 12 pneumococcal serotypes were identified, including: 19F (69.5%), 19A (7.5%), 9V
(4.4%), 9A (3.8%), 6A (2.5%), 20 (1.9%), 23A (1.2%), 15A (1.2%), 6B (1.2%), 34 (0.6%), 6C
(0.6 %), 33A/33F (0.6%), 34 (0.6%). There were 7 samples of other pneumococcal types (4.4%), 1
sample that similar sequences not found (0.6%). PCV13 covered 5 pneumococcal serotypes
(81.3%), while PCV7 and PCV10 covered 3 types (69.5%). PCV13 covered not only all PCV7 and
PCV10-related serotypes but also 6A and 19A serotype.
Conclusion: There were 12 pneumococcal serotypes identified and the most common serotypes
were 19F, 19A, 9A, 9V, and 6A. Most of the common serotypes are covered by pneumococcal
vaccines. In terms of vaccine coverage, PCV13 is more effective than PCV7 and PCV10.
Article Details
Keywords
Community-acquired pneumonia, S.pneumonia, pneumococcal vaccine.
References
Burden of disease caused by Streptococcus
pneumoniae in children younger than 5 years:
global estimates. Lancet. Sep 12
2009;374(9693):893-902.
2. Sandgren A, Sjostrom K, OlssonLiljequist B et al., Effect of clonal and
serotype-specific properties on the invasive
capacity of Streptococcus pneumoniae. J Infect
Dis. Mar 1 2004;189(5):785-96.
3. Song JH, Jung SI, Ko KS et al., High
prevalence of antimicrobial resistance among
clinical Streptococcus pneumoniae isolates in
Asia (an ANSORP study). Antimicrob Agents
Chemother. Jun 2004;48(6):2101-7.
4. Partridge SR, Analysis of antibiotic
resistance regions in Gram-negative bacteria.
FEMS Microbiol Rev. Sep 2011;35(5):820-55.
5. Imöhl M, Reinert RR, Ocklenburg C et
al., Association of serotypes of Streptococcus
pneumoniae with age in invasive pneumococcal
disease. J Clin Microbiol. Apr
2010;48(4):1291-6.
6. Hausdorff WP, Feikin DR, Klugman KP,
Epidemiological differences among
pneumococcal serotypes. Lancet Infect Dis. Feb
2005;5(2):83-93.
7. Fraser D, Givon-Lavi N, Bilenko N et al.,
A decade (1989-1998) of pediatric invasive
pneumococcal disease in 2 populations residing
in 1 geographic location: implications for
vaccine choice. Clin Infect Dis. Aug 15
2001;33(4):421-7.
8. Trần Anh Tuấn, Phác đồ điều trị nhi khoa.
Viêm phổi. Nhà xuất bản Y học; 2013.
9. Pneumonia Guidelines for the
management of common childhood illnessses
76-90 (2013).
10. Bùi Tùng Hiệp, Khảo sát tình hình sử
dụng kháng sinh trong điều trị viêm phổi ở trẻ
em dưới 5 tuổi tại Bệnh viện Đa khoa Khu vực
Hồng Ngự, Tạp chí Y học Việt Nam. 2018:3.
11. Nguyễn Thị Thu Huyền, Đặc điểm
dịch tễ học lâm sàng và kết quả điều trị viêm
phổi do phế cầu ở trẻ em dưới 5 tuổi tại Bệnh
viện Trung ương Thái Nguyên. Luận văn Thạc
sĩ. Trường Đại học Y Hà Nội; 2020.
12. Tống Thị Hà, Nghiên cứu sự lưu hành
các typ huyết thanh và kiểu gen kháng kháng
sinh của Streptococcus pneumonia gây bệnh
bằng kỹ thuật PCR đa mồi tại một số địa
phương ở Việt Nam, Luận án Tiến sĩ Trường
Đại học Khoa học tự nhiên - Đại học Quốc gia
Hà Nội; 2017.
13. Isaacman DJ, McIntosh ED, Reinert
RR, Burden of invasive pneumococcal disease
and serotype distribution among Streptococcus
pneumoniae isolates in young children in
Europe: impact of the 7-valent pneumococcal
conjugate vaccine and considerations for future
conjugate vaccines. Int J Infect Dis. Mar
2010;14(3):e197-209.
14. Kandasamy R, Lo S, Gurung M et al.,
Effect of childhood vaccination and antibiotic
use on pneumococcal populations and genomewide associations with disease among children
in Nepal: an observational study. Lancet
Microbe. Jul 2022;3(7):e503-e511.
15. Harrison CJ, Woods C, Stout G et al.,
Susceptibilities of Haemophilus influenzae,
Streptococcus pneumoniae, including serotype
19A, and Moraxella catarrhalis paediatric
isolates from 2005 to 2007 to commonly used
antibiotics. J Antimicrob Chemother. Mar
2009;63(3):511-9.