FACTORS ASSOCIATED WITH EXACERBATIONS REQUIRING HOSPITALIZATION AMONG COPD OUTPATIENTS AT VIET TIEP FRIENDSHIP HOSPITAL IN 2025

Nguyen Quang Hung1, Nguyen Huy Hoang1, Nguyen Quang Dao2
1 Department of Otorhinolaryngology, Viet Tiep Friendship Hospital
2 Hai Phong University of Medicine and Pharmacy

Main Article Content

Abstract

Objective: Chronic Obstructive Pulmonary Disease (COPD) causes irreversible airflow limitation, progressively worsening over time, and significantly impairs patients' quality of life. Understanding the combined risk factors and the level of disease control will contribute to supplementing scientific evidence for disease management and prevention. The objective of this study is to identify factors associated with exacerbations requiring hospitalization among COPD outpatients.


Methods: A cross-sectional descriptive study was conducted on 187 outpatients (stages 1-4) diagnosed with COPD at Viet Tiep Friendship Hospital, Hai Phong city from January to March 2025.


Results: Most of the study subjects were over 60 years old (89.8%) and predominantly male (74.3%). The proportion of patients with exacerbations requiring hospitalization was 43.9%. The study identified factors that significantly increased the risk of hospitalization due to exacerbations, including having a history of smoking (OR = 2.40); mMRC dyspnea grade 4 (OR = 5.00); and severe COPD classifications such as Group C (OR = 5.10) and Group D (OR = 17.9). Conversely, factors that helped reduce the risk of hospitalization included: female gender (OR = 0.40 compared to male), education level above high school (OR = 0.56 compared to below high school), and the habit of regular physical exercise (OR = 0.50 compared to no exercise behavior).


Conclusion: Gender, educational level, smoking history, physical exercise habits, degree of dyspnea (mMRC), and COPD classification are factors directly associated with hospitalization due to exacerbations in COPD patients.

Article Details

References

[1] World Health Organization. Chronic obstructive pulmonary disease (COPD). 2024; Available from: https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pulmonary-disease-%28copd%29?utm_source=chatgpt.com.
[2] Global Initiative for Chronic Obstructive Lung Disease, Pocket Guide to COPD Diagnosis Management and Prevention, Global Initiative for Chronic Obstructive Lung Disease. 2024.
[3] Vos, T., Lim, S.S., Abbafati, C., et al., Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The lancet, 2020. 396(10258). 1204-1222. 10.1016/S0140-6736(20)30925-9.
[4] Ngô Quý Châu. Nghiên cứu dịch tễ học bệnh phổi tắc nghẽn mạn tính ở một số tỉnh thành phố khu vực phía bắc Việt Nam. Tạp chí Y học lâm sàng-Bệnh viện Bạch Mai, 2006. 11. 59-64.
[5] Phạm Anh Tuấn, Phạm Thùy Trâm, Phạm Thanh Vũ, et al., Yếu tố nguy cơ liên quan đến tần suất đợt cấp ở bệnh nhân bệnh phổi tắc nghẽn mạn tính tại bệnh viện quận 11. Tạp chí Y học Việt Nam, 2025. 553(3). 10.51298/vmj.v553i3.15448
[6] Bệnh viện Hữu nghị Việt Tiệp. Giới thiệu – quy mô và hoạt động-lịch sử phát triển Bệnh viện Hữu Nghị Việt Tiệp. Available from: https://viettiephospital.vn/.
[7] Phan Thanh Thuỷ, Vũ Văn Giáp, Nguyễn Viết Nhung. Đặc điểm lâm sàng và tỷ lệ đợt cấp bệnh phổi tắc nghẽn mạn tính của người bệnh tại một số đơn vị quản lý ngoại trú. Tạp chí Nghiên cứu Y học, 2022. 160(12V1). 228-236. 10.52852/tcncyh.v160i12V1.1218
[8] Trần Văn Ngọc, Mã Vĩnh Đạt. Đặc điểm lâm sàng và yếu tố thúc đẩy vào đợt cấp bệnh phổi tắc nghẽn mạn tính nhập viện thường xuyên ở nhóm nguy cơ cao. Y học Thành Phố Hồ Chí Minh, 2018. 22(2). 186-193.
[9] Stolz, D., Kostikas, K., Loefroth, E., et al., Differences in COPD exacerbation risk between women and men: analysis from the UK clinical practice research datalink data. Chest, 2019. 156(4). 674-684. 10.1016/j.chest.2019.04.107
[10] Zysman, M. and Raherison-Semjen, C., Women's COPD. Frontiers in medicine, 2022. 8. 600107. https://doi.org/10.3389/fmed.2021.600107.
[11] Dong, H., Hao, Y., Li, D., et al., Risk factors for acute exacerbation of chronic obstructive pulmonary disease in industrial regions of China: a multicenter cross-sectional study. International Journal of Chronic Obstructive Pulmonary Disease, 2020. 2249-2256. https://doi.org/10.2147/copd.s270729
[12] Park, H., Jo, S.M., Jin, K.N., et al., Distinct risks of exacerbation and lung function decline between never-smokers and ever-smokers with COPD. BMC Pulmonary Medicine, 2025. 25(1). 138. 10.1186/s12890-025-03604-1.
[13] Yang, B., Lee, H., Ryu, J., et al., Impacts of regular physical activity on hospitalisation in chronic obstructive pulmonary disease: a nationwide population-based study. BMJ Open Respiratory Research, 2024. 11(1). 10.1136/bmjresp-2023-001789
[14] Asai, N., Ohkuni, Y., Ohashi, W., et al., Modified MRC assessment and FEV1. 0 can predict frequent acute exacerbation of COPD: An observational prospective cohort study at a single-center in Japan. Respiratory medicine, 2023. 212. 107218. 10.1016/j.rmed.2023.107218