RESEARCH ON PREGNANCY OUTCOMES OF HIV/AIDS INFECTED WOMEN GIVING BIRTH AT HANOI OBSTETRICS AND GYNECOLOGY HOSPITAL
Main Article Content
Abstract
Objectives: Describe the clinical characteristics of HIV/AIDS infected pregnant women giving birth at Hanoi Obstetrics and Gynecology Hospital and their pregnancy outcomes.
Subjects and methods: Retrospective cross-sectional study of 100 pregnant women diagnosed with HIV infection and giving birth at Hanoi Obstetrics and Gynecology Hospital from January 1, 2022 to December 31, 2023.
Results: The average age of the participants was 32.44 ± 6.18 years old. Most pregnant women had one or more children, and none reported having an HIV-infected child. The majority of pregnant women ended their pregnancy by cesarean section, accounting for 87%. Among HIV-infected pregnant women undergoing cesarean section, 80.4% were performed for obstetric indications, with previous cesarean scars representing the most common reason (65.8%). In contrast, 13.8% of cesarean deliveries were indicated for the prevention of mother-to-child transmission (PMTCT). The use of PMTCT drugs significantly influenced the choice of delivery method, the difference was significant with p < 0.001. Regarding neonatal outcomes, most pregnancies were full-term (≥37 weeks), accounting for 89% of the cases. The majority of newborns weighed between 2500 g and 3500 g (90%), and 98% were HIV-negative. There was a statistically significant association between the newborns’ HIV status and both PMTCT drug use (p < 0.001) and mode of delivery (p = 0.008).
Conclusion: The rate of HIV infection among newborns is 2%. The majority of HIV-infected pregnant women delivered by cesarean section, with previous surgical scars representing the most common indication. The combined use of PMTCT interventions and cesarean delivery was associated with a reduced risk of mother-to-child HIV transmission. Furthermore, PMTCT drug use had a significant influence on the choice of delivery method, suggesting that antiretroviral prophylaxis played an important role in clinical decision-making regarding mode of delivery.
Article Details
Keywords
HIV-infected pregnant women, PMTCT, cesarean section
References
[2] Nguyễn Liên Phương, “Nhận xét về thái độ xử trí trong chuyển dạ của sản phụ có HIV/AIDS năm 2008 tại bệnh viện Phụ sản Trung ương,” luận văn bác sỹ chuyên khoa II, Đại học Y Hà Nội, 2009.
[3] Mai Thị Anh, “Nghiên cứu thái độ xử trí sản khoa ở sản phụ nhiễm HIV/AIDS đẻ tại Bệnh viện phụ sản Trung Ương trong 2 năm 2012-2013,” luận văn thạc sỹ y học, Đại học Y Hà Nội, 2014.
[4] Đỗ Mạnh Tùng, “Nghiên cứu thái độ xử trí trong chuyển dạ ở sản phụ nhiễm HIV/AIDS tại bệnh viện Phụ sản Trung Ương trong hai giai đoạn 2005-2015,” luận văn thạc sỹ y học, Đại học Y Hà Nội, 2016.
[5] S. Ferrero, G. Gotta, G. Melica, B. Biasotti, G. Ravera, and G. Bentivoglio, “162 HIV-1 infected pregnant women and vertical transmission. Results of a prospective study,” Minerva Ginecol, vol. 54, no. 5, pp. 373–385, Oct. 2002.
[6] S. Ferrero and G. Bentivoglio, “Post-operative complications after caesarean section in HIV-infected women,” Arch Gynecol Obstet, vol. 268, no. 4, pp. 268–273, Oct. 2003, doi: 10.1007/s00404-002-0374-8.
[7] L. Mandelbrot et al., “Perinatal HIV-1 transmission: interaction between zidovudine prophylaxis and mode of delivery in the French Perinatal Cohort,” JAMA, vol. 280, no. 1, pp. 55–60, Jul. 1998, doi: 10.1001/jama.280.1.55.
[8] Lương Tâm Phúc, “Nhận xét việc theo dõi thai và xử trí sản phụ nhiễm HIV đẻ tại Bệnh viện Phụ sản Hà Nội trong 5 năm 2006-2010,” Đại học Y Hà Nội, 2011.
[9] Đỗ Thu Thủy, “Tình hình lây truyền HIV từ mẹ sang con tại bệnh viện Phụ sản Hải Phòng giai đoạn 2004-2008,” Tạp chí hội nghị sản phụ khoa Việt Pháp 2009, pp. 18–24, 2008.