ANALGESIC EFFECTS OF PEPPERMINT ESSENTIAL OIL (MENTHA PIPERITA) IN MUSCLE PAIN AND TENSION-TYPE HEADACHE: A CLINICAL REVIEW
Main Article Content
Abstract
Objectives: To synthesize clinical evidence on the analgesic effects of peppermint essential oil (PEO) for muscle pain and tension-type headache, and to position PEO within current multimodal care.
Methods: We searched PubMed, Cochrane, and major publishers (January 2010 to October 2025) using terms related to peppermint oil/menthol, tension-type headache, myalgia, and randomized controlled trials. Inclusion prioritized randomized or controlled studies, systematic reviews, and mechanistic reviews relevant to topical PEO or menthol in humans. Evidence was summarized narratively with emphasis on clinical applicability.
Results: For tension-type headache, controlled crossover trials show that 10% peppermint oil in ethanol significantly reduces headache intensity versus placebo within 15-60 minutes; efficacy appears comparable to 1000 mg Paracetamol in acute tension-type headache with favorable tolerability. A later narrative review concludes PEO 10% is licensed for acute tension-type headache in adults and children ≥ 6 years in some jurisdictions and is considered a standard option for acute therapy. For musculoskeletal pain, randomized and controlled studies suggest topical menthol decreases pain associated with delayed-onset muscle soreness and chronic regional pain, with small-to-moderate effects; a 2023 systematic review indicates essential-oil topicals can reduce pain and stiffness when used as add-on therapy. Mechanistically, menthol activates TRPM8 and modulates nociception, supporting counterirritation and cooling analgesia. Adverse effects are uncommon and mild with topical use; ingestion is not recommended.
Conclusion: Topical peppermint oil/menthol can provide short-term analgesia for acute tension-type headache and mild-to-moderate muscle pain, particularly as an adjunct to guideline-based care (exercise, education, first-line analgesics). Higher-quality, parameter-standardized RCTs with longer follow-up are warranted to refine indications and dosing.
Article Details
Keywords
Peppermint essential oil, menthol, tension-type headache, muscle pain, topical analgesic.
References
[2] Göbel H, Schmidt G et al. Effect of peppermint and eucalyptus oil preparations on neurophysiological and experimental algesimetric headache parameters. Cephalalgia, 1994, 14 (3): 228-234.
[3] Göbel H, Heinze A, Heinze-Kuhn K et al. Peppermint oil in the acute treatment of tension-type headache. Schmerz, 2016, 30 (3): 295-310.
[4] Bakó E, Erdő-Bonyár S, Hidvégi E et al. Efficacy of topical essential oils in musculoskeletal disorders: A systematic review and meta-analysis. Medicines (Basel), 2023, 10 (1): 11.
[5] Johar P et al. A comparison of topical Menthol to ice on pain, evoked potentials, and skin temperature during delayed-onset muscle soreness. Int J Sports Phys Ther, 2012, 7 (4): 314-322.
[6] Stefanelli L, Marsili M, Allocca G et al. Delayed-onset muscle soreness and topical analgesic (Menthol): Neurophysiological evidence. J Pain Res, 2019, 12: 3101-3110.
[7] Sundstrup E, Jakobsen M.D, Jay K et al. Acute effect of topical menthol on pain in chronic pain patients: randomized controlled study. Biomed Res Int, 2014: 310913.
[8] Li Z, Yu T, Zhao P et al. The distinctive role of menthol in pain and analgesia. Front Mol Neurosci, 2022, 15: 1006908.