RISK FACTORS FOR SEVERE HAND FOOT AND MOUTH DISEASE INPATIENT TREATMENT IN THAI BINH PEDIATRIC HOSPITAL

Vu Thi Phuong1
1 Thai Binh Pediatric Hospital

Main Article Content

Abstract

Objectives: To identify potential risk factors for severe hand, foot and mouth disease in children,
were treated in Thai Binh Pediatric Hospital from 6/2020 to 6/2021.
Subjects and methods: This is a retrospective and prospective descriptive study on 1081 HFMD
inpatient treatment in Thai Binh Pediatric Hospital.
Results: The risk factors for severe disease include: Clinicals: high fever more than 39ºC (OR=3),
startle (OR=10.4) with p <0.05. Paraclinicals: White blood cell > 16 000 cell/mm3 (OR=2), with
p<0.05; GOT increased (OR=2.5) and blood sugar increased (OR=3.8), with p < 0.05; EV71: In the
EV71-positive group, the severe group was 34.2%, much higher than the mild group (19.8%). The
difference was statistically significant with p < 0.05.

Article Details

References

[1] Wang J, Guo YS, Christakos G, Hand, foot and
mouth disease: spatiotemporal transmission and
climate. Int J Health Geogr, 2011, 10, 25.
[2] Ministry of Publish Health, Guidelines for
diagnosis and treatment hand foot mouth disease,
2011.
[3] Wang YH, Zhao H, Ou R, Epidemiological and
clinical characteristics of severe hand-foot-andmouth disease (HFMD) among children: a 6-year
population-based study. BMC Public Health
volume 20, Article number: 801, 2020.
[4] Thanh DQ, The risk factors of acquiring severe
hand foot and mouth disease in children, 2020.
[5] Thu NK, The clinical, paraclinical charasteristics
and causes of hand foot and mouth disease in
Viet Nam. Doctoral thesis, Ha Noi Medical
University, 2016.
[6] Hung TQ, Epidemiology characteristics of hand
foot and mouth disease in Dac Lac Viet Nam.
Doctoral thesis, Hue University of Medicine and
Pharmacy, 2017.
[7] Zhou H, Guo S, Zhou H et al., Clinical
characteristics of hand, foot and mouth disease in
Harbin and the prediction of severe cases. Chinese
Medical Journal, 2012, 125(7), 1261-1265.
[8] Yang T, Xu G, Dong H et al., A case-control
study of risk factors for severe hand-foot-mouth
disease among children in Ningbo, China, 2010-
2011. Eur J Pediatr, 2012, 171(9), pp. 1359-1364.
[9] Thuong TC, Hung NT, Niem DV et al., Prognosis
factors of hand foot and mouth diesae cause by
enterovirus. Thanh Pho Ho Chi Minh Journal of
Medicine, 2011, 15(3).
[10] Chong CY, Chan KP, Shah VA eta al., “Hand, foot
and mouth disease in Singapore: a comparison of
fatal and non-fatal cases”. Acta Paediatr, 2003,
92(10), pp. 1163-1169.
[11] Yuyun L, Runan Z, Yuan Q et al., “The
characteristics of blood glucose and WBC counts
in peripheral blood of cases of hand foot and
mouth disease in China: a systematic review”,
PLoS One, 2012, 7(1), pp. e29003.
[12] Chang LY, Lin TY, Hsu KH et al., Clinical
features and risk factors of pulmonary oedema
after enterovirus-71-related hand, foot and mouth
disease. Lancet, 1999, 354(9191), pp. 1682-1686.
[13] Fang Y, Wang S, Zhang L et al., “Risk factors
of severe hand, foot and mouth disease: a metaanalysis”, Scand J Infect Dis, 2014, 46(7), pp.
515-522.