ASSESSMENT OF KI-67 EXPRESSION IN HISTOPATHOLOGICAL SUBTYPES NON-HODGKIN'S B-CELL LYMPHOMA
Main Article Content
Abstract
Objective: Histopathology classification of non-Hodgkin’s lymphoma (NHL) B-cell lineage and
evaluation of the immunohistochemical expression of Ki67 marker in histopathological subtypes
Non-Hodgkin’s B-cell lymphoma.
Matherial and Methods: A cross-sectional study of formalin-fixed paraffin-embedded samples
of 69 patients were confirmed as non-Hodgkin lymphoma B-cell (NHL) by histopathological and
immunohistochemistry techniques from January 2018 to January 2021, at Military Hospital 103.
Comment on histopathological characteristics, immunohistochemical expression marker and the
collected data analysis.
Result: Diffuse large B-cell lymphoma is the most common histopathologic subtype (76.80%), with
the average expressional value of Ki67 is 62.9 ± 14.7, the lowest value is 20, the highest is 90. The
Ki67 index of the FL, SLL/CLL, and MCL subtypes ranges from 20-30%, while the MZL has a Ki67
value ranging from 5-80%.
Conclusion: The Ki67 marker was expressed at a high rate in diffuse large B-cell lymphoma,
especially at a high level (≥65%) in most of the non-germinal center group.
Article Details
Keywords
Non-Hodgkin’s lymphoma (NHL), Ki67 marker.
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