NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CỘNG HƯỞNG TỪ, ĐẶC ĐIỂM MỘT SỐ DẤU ẤN SINH HỌC VÀ KẾT QUẢ BƯỚC ĐẦU ĐIỀU TRỊ U TẾ BÀO THẦN KINH ĐỆM BẬC CAO

Abstract

Objectives: To investigate the clinical characteristics, magnetic resonance, P53 gene mutation, IDH of grade III and IV of glial cell tumors with the indication for surgery combined with radiotherapy and chemotherapy. Initial assessment of treatment results for high-level diabetic cancer. Subjects and research methods: Patients with high grade of glial cell tumors undergo surgery, histopathology diagnosis, immunohistochemistry to identify mutations (IDH, p53, MGMT) and radiotherapy and chemotherapy incorporated at K hospital. Tumor and combined chemotherapy. Evaluation of clinical symptoms at admission, tumor characteristics on magnetic resonance film, initial results after tumor removal surgery and based on the Karnofski scale to assess the patient's previous nervous system rehabilitation and after surgery. Results: Average age 45 ± 15.7, ratio male/female = 32/19. The main reasons for hospital admission of the patient were headache, hemiplegia, and epilepsy. Magnetic resonance imaging showed that most tumors have clear boundaries, mixed structure, heterogeneous signals, strong drug infiltration after injection, with cerebral edema around tumors but little surrounding invasion, no calcification or bleeding. The results of surgical treatment showed that over 90% of the patients were all taken and the majority of tumors were removed, the postoperative Karnofsky score increased more than before surgery, but the difference was not statistically significant. Conclusion: Patients with high grade of glial cell tumors have the main clinical symptoms of intracranial hypertension syndrome, characterized by well-defined, mixed-structure tumors. less invasive around. Surgical treatment for the majority of tumors showed an improvement in postoperative nervous system function.