17. VACUUM BLOOD TUBES: DEVELOPMENT AND APPLICATIONS IN MODERN MEDICINE

Nguyen Minh Son1, Lam Kien Thanh1, Phan Viet Anh Viet Vuong2, Le Van Chuong1
1 Faculty of Medical Technology, Van Lang University
2 Research and Development Department, Wembley Medical Company

Main Article Content

Abstract

Objective: To review the development, characteristics, advantages, and challenges of vacuum blood collection tubes in clinical testing compared to traditional methods.


Methods: Literature search was conducted on PubMed, from 2010-2024 using keywords: “vacuum blood collection tubes”, “preanalytical errors”, “hemolysis”, “sample quality”… Selection criteria included studies on sample quality, preanalytical factors, and hemolysis reduction solutions.


Results: Vacuum blood collection tubes significantly improve sample quality, efficiency, and safety compared to traditional methods. Hemolysis remains a major challenge, especially in emergency departments (rates up to 35%), and pediatric specimens. Using smaller volume tubes (2 mL versus 6 mL) can decrease hemolysis rates from 11.8% to 2.9%. Proper tube selection, correct sampling technique, and staff training are important factors affecting sample quality.


Conclusion: Vacuum blood collection tubes provide significant benefits in reducing pre-analytical errors, enhancing safety protocols, and cost-effectiveness. Current research trends focus on developing patient-specific tubes and integration with automated systems.

Article Details

References

[1] Simundic A.M, Bölenius K, Cadamuro J et al, Joint EFLM-COLABIOCLI Recommendation for venous blood sampling, Clin Chem Lab Med, 2018, 56 (12): 2015-38.
[2] Hu J, Zhang Q.X, Xiao T.T et al, Residual Negative Pressure in Vacuum Blood-Collection Tube and Hemolysis in Pediatric Blood Specimens, Lab Med, 2020, 51 (1): 41-6.
[3] Clinical and Laboratory Standards Institute, Collection of diagnostic venous blood specimens, CLSI, 2017.
[4] Heiligers-Duckers C, Peters N, van Dijck J.J.P et al, Low vacuum and discard tubes reduce hemolysis in samples drawn from intravenous catheters, Clin Biochem, 2013, 46 (12): 1142-4.
[5] Simundic A.M, Cornes M.P, Grankvist K et al, Colour coding for blood collection tube closures-a call for harmonisation, Clin Chem Lab Med, 2015, 53 (3): 371-6.
[6] Chung H.J, Song Y.K, Hong S.K et al, Implementation of biological variation-based analytical performance specifications in the laboratory: Stringent evaluation of Improvacutor blood collection tubes, PLoS One, 2017, 12 (12): e0189882.
[7] Wembley Medical, Ống nghiệm lấy máu chân không VATRACY, [Online], 2024 [cited 2024 Mar 20], [1 screen], Available from: URL: https://wembleymed.com.vn/vi/
[8] Neuwinger N, Meyer Zum Buschenfelde D, Tauber R et al, Underfilling of vacuum blood collection tubes leads to increased lactate dehydrogenase activity in serum and heparin plasma samples, Clin Chem Lab Med, 2020, 58 (2): 213-21.
[9] Kocijancic M, Cargonja J, Delic-Knezevic A, Evaluation of the BD Vacutainer RST blood collection tube for routine chemistry analytes: clinical significance of differences and stability study, Biochem Med (Zagreb), 2014, 24 (3): 368-75.
[10] Phelan M.P, Reineks E.Z, Berriochoa J.P et al, Impact of use of smaller volume, smaller vacuum blood collection tubes on hemolysis in emergency department blood samples, Am J Clin Pathol, 2017, 148 (4): 330-5.