5.FACTORS RELATED TO SERUM ANTI-MULLERIAN HORMONE LEVELS CHANGES AT 3 MONTHS AFTER LAPAROSCOPIC ENDOMETRIOMA CYSTECTOMY
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Abstract
Objective: To evaluate factors related to serum anti-mullerian hormone (AMH) levels changes at 3 months after laparoscopic endometrioma cystectomy.
Materials and method: A prospective longitudinal study was conducted at Hanoi Obstetrics and Gynecology Hospital from 1/2015 to 10/2016. We recruited 104 women aged 18-40, with ovarian endometriosis, which was confirm in post-operative pathology, and underwent laparoscopic endometrioma cystectomy. The excluded criteria consist of post-menopause, polycystic ovarian syndrome, previous ovarian surgery, combined with other ovarian disorders, hormone disorders, being pregnant during study period and refusal participation. Participant’s characteristics, endometriomas and surgery was collected, and 3-month post-operation.
Results: The mean age of participants was 29 years. At 3-month postoperation, the mean AMH level decreased significantly compared to preoperatoin, from 4.47 ng/ml to 1.96 ng/ml (p < 0.001). The magnitude of AMH level decline were 48.7 ± 34.1%. The AMH levels decreased more in women < 30 years old (55.5% vs 37% in > 30 years old), bilateral cyst (72% vs 40.5% in unilateral cyst), cyst diameter > 6 cm when cysts are on one ovary (52% vs 36.2% in cysts < 6 cm) and cyst at stage 4 according to rASRM (59.3% vs 39.6% in stage 3). The changes of AMH levels was independent to BMI and CA125 levels.
Conclusions: Factors related to AMH level decreasing at 3 months after laparoscopic endometrioma cystectomy included young women, and bilateral, large, 4-stage according to rASRM cysts.
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Keywords
Laparoscopic cystectomy of endometriomas, AMH, related factors, 3-month postoperation
References
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