32. COMMENTS ON THE RESULTS OF ENDOTRACHEAL ANESTHESIA IN ENDOSCOPIC SURGERY FOR BENIGN ADRENAL TUMORS AT THE CENTRAL ENDOCRINOLOGY HOSPITAL

Tran Ngoc Tuan1
1 National Hospital of Endocrinology

Main Article Content

Abstract

Through research on anesthesia and 24-hour perioperative resuscitation for 75 patients undergoing adrenal adenoma surgery, we drew the following conclusions:


1. Pheochromocytoma patients requyred 7-10 days of treatment with alpha-blockers or combined beta-blockers to stabilize blood pressure and heart rate before surgery. High blood pressure and hypokalemia must be managed before surgery. During adrenal tumor surgery, invasive arterial blood pressure monitoring is essential, along with additional central venous lines for recurrent or enlarged adenomas. Urinary and gastric catheters should be placed, and medications for blood pressure and heart rhythm control prepared. Hydrocortisone supplementation during and after surgery to prevent adrenal insufficiency. Anesthesiologists must coordinate with surgeons to maintain stable blood pressure during tumor manipulation (when the surgeon pulls or dissects the tumor causing increased blood pressure; the surgeon clamps the main adrenal vein causing hypotension).


2. Endotracheal anesthesia provided effective anesthesia for adrenal gland tumor surgeries, with an average duration of 72.2 ± 16.3 minutes. Conn’s syndrome and pheochromocytoma patients requyre more anesthetics and muscle relaxants than those with non-secreting tumors or Cushing's syndrome. Hemodynamic disturbances occurred in all patients with Conn's syndrome, Cushing's syndrome, and pheochromocytoma, but only in 2 of 13 (11.5%) with non-secreting tumors. Medication is administered to stabilize heart rate and blood pressure in these cases. No significant difference in average blood pressure and heart rate was observed between pheochromocytoma and adrenocortical tumor patients 30 minutes before and 3 hours after surgery, but significant differences were noted during surgery (p < 0.05). All patients had good respiratory status before and after surgery, and both patients and surgeons were satisfied with the anesthesia 48 hours post-surgery

Article Details

References

[1] Berends AMA, Kerstens MN, Lenders JWM, Timmers HJLM, Approach to the Patient: Perioperative Management of the Patient with
Pheochromocytoma or Sympathetic Paraganglioma, J Clin Endocrinol Metab, 2020, 105.
[2] Kim WW, Kim DH, Cho JW et al, The association between the type of anesthesia and hemodynamic instability during pheochromocytoma
surgery: a retrospective cohort study, Surg Endosc, 2022, 36: 5491.
[3] Domi R, Sula H, Pheochromocytoma, the challenge to anesthesiologist, J Endocrinol Metab, 2011, 1(3):97-100.
[4] Naranjo J, Dodd S, Martin YN, Perioperative Management of Pheochromocytoma, J Cardiothorac Vasc Anesth, 2017, 31: 1427.
[5] Patel D, Phay JE, Yen TWF et al, Update on Pheochromocytoma and Paraganglioma from the SSO Endocrine and Head and Neck Disease
Site Working Group, Part 2 of 2: Perioperative Management and Outcomes of Pheochromocytoma and Paraganglioma, Ann Surg Oncol,
2020, 27: 1338.
[6] Sauneuf B, Chudeau N, Champigneulle B et al, Pheochromocytoma Crisis in the ICU: A French Multicenter Cohort Study With Emphasis on
Rescue Extracorporeal Membrane Oxygenation, Crit Care Med, 2017, 45: e657.
[7] Groeben H, Walz MK, Nottebaum BJ et al, International multicentre review of perioperative management and outcome for catecholamine-producing tumours, Br J Surg, 2020, 107: e170.
[8] Takeda T, Hakozaki K, Yanai Y et al, Risk factors for haemodynamic instability and its prolongation during laparoscopic adrenalectomy
for pheochromocytoma, Clin Endocrinol (Oxf), 2021, 95: 716.
[9] Weingarten TN, Welch TL, Moore TL et al, Preoperative Levels of Catecholamines and Metanephrines and Intraoperative Hemodynamics of Patients Undergoing Pheochromocytoma and Paraganglioma Resection, Urology, 2017, 100: 131.
[10] Wiseman D, McDonald JD, Patel D et al, Epidural anesthesia and hypotension in pheochromocytoma and paraganglioma, Endocr Relat Cancer, 2020, 27: 519.
[11] Wu S, Chen W, Shen L et al, Risk factors for prolonged hypotension in patients with pheochromocytoma undergoing laparoscopic adrenalectomy: a single-center retrospective study, Sci Rep, 2017, 7: 5897.