CLINICAL AND SUBCLINICAL CHARACTERISTICS ON BREAST CANCER PATIENTS TREATED WITH ANTHRACYCLINES

Bui Dang Minh Tri1, Doan Thanh Truc, Tri Kim Ngoc2, Vo Van Cuong3
1 University of Medicine Pham Ngoc Thach
2 Tay Do University
3 Cuong

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Abstract

Objective: Describing the clinical and subclinical characteristics on breast cancer patients treated with Anthracyclines at Thong Nhat hospital.Subjects and methods: a prospective descriptive study on 43 patients with breast cancer was treated with Anthracyclines with 4 to 6 cycles as determined by clinical doctor at Thong Nhat hospital. Results: Average age: 49.2 ± 3.2 years old. The age group accounted for the largest proportion in the study object was the 50-60 age group (48.84%). The percentage of patients who self-examined the tumor was the highest with 79.07%. There were 9.30% of patients with pain symptoms, 11.63% of patients with nipple discharge. Tumor position in the upper-external quadrant accounted for the largest percentage with 55.81%. The average size of tumors was 2.56 ± 1.2 (cm). The main form of lesions detected on ultrasound was the local lesion with over 80% with an unknown boundary
feature (81.40%) and predominantly invasive (76.74%). The histopathological type accounted for the highest percentage was the invasive tubular carcinoma (79.07%), the medullary carcinoma and
mucinous carcinoma body accounted for the lowest rate with 2.33% and 0%, respectively. The histological degree accounted for the highest percentage among the research subjects was degree 2
with 50.18%. Stage III accounted for the highest rate with 46.51%.
Conclusion: The most common age group for breast cancer was 50-60 years old, the main symptom was self-examination with breast tumors, breast cancer were mainly local tumor at the upper-external
position. On ultrasound, the lesions were the local, unknown boundary, and invasive lesions. Breast cancer was mainly invasive ductal carcinoma, histologic degree 2.

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References

[1] Lan NTM, Research on the incidence of breast cancer in Hanoi women in the period 2014 - 2016, PhD thesis, Hanoi Medical University, 2020. (in Vietnamese)
[2] Huyen PT, Evaluation of results of adjuvant chemotherapy regimen 4AC + 4T combined with trastuzumab on patients with breast cancer stage II, III with Her 2 neu positive, Doctor of Medicine Thesis, Hanoi medical university, 2016. (in Vietnamese)
[3] Thuan DC, Research on imaging characteristics, pathology and endocrine receptor status in breast cancer at Hue University of Medicine and Pharmacy hospital, Journal of Obstetrics and Gynecology, 2012; 3(10): 250-257. (in Vietnamese)
[4] Quang LH, Application of imaging techniques and biopsy of the portal lymph nodes in the assessment of axillary lymph node metastasis in breast cancer patients, Doctor of Medicine Thesis, Hanoi Medical University, 2012. (in Vietnamese)
[5] Veronesi U, Viale G, Paganelli G et al., Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled study, Ann Surg., 2010; 251: 595-600.
[6] Langer I, Guller U, Berclaz G et al., Morbidity of sentinel lymph node biopsy (SLN) alone versus SLN and completion axillary lymph node dissection after breast cancer surgery a prospective Swiss multicenter study on 659 patients, Ann Surg., 2007; 245(3): 134-8.