37. EVALUATING THE TREATMENT OUTCOMES OF NEONATAL PERTUSSIS AT THE NATIONAL CHILDREN'S HOSPITAL (2019 -2020)
Main Article Content
Abstract
Objectives: Treatment outcomes of pediatric patients with pertussis treated at the Vietnam National
Children's Hospital
Methods: The study was designed using uncontrolled intervention research method.
Results: The study was conducted on 382 pediatric patients aged < 16 years old diagnosed with
pertussis at the National Children's Hospital from January 1, 2019 to December 31, 2020, 95.5%
(365/382) of the children were prescribed macrolide antibiotics at the hospital. The percentage of
children with severe pertussis using macrolide antibiotics was 92.2%. 12.3% (47/382) of the children
had to be admitted to the Resuscitation Unit with the average stay of 10 days (1 day as the shortest
duration, and 60 days as the longest duration). 44.5% (170/382) of the children needed oxygen
therapy, 9.2% (35/382) needed mechanical ventilation, 4.5% (17/382) used IVIG; 0.8% (3/382)
required ECMO, and 0.5% (2/382) required dialysis. After 25.8 ± 10.5 days, the real-time PCR of
pertussis patients turned to negative. 92.9% of the patients were cured with the average hospital stay
of 12.95 ± 10.47 days. The children with severe pertussis had a longer hospital stay than others (15
days vs. 8 days). The mortality rate was 1.6%.
Conclusions: The macrolide antibiotics was still highly effective in the treatment of neonatal
pertussis with the cure rate of 92.9%.
Article Details
Keywords
Pediatric patients, pertussis, cured
References
Tuấn, Đặc điểm bệnh nhân ho gà tại Bệnh viện
Nhi Trung ương năm 2015; Tạp chí Y học Dự
phòng, 27(6), 2017, 69–76.
[2] Trần Đăng Xoay, Một số yếu tố liên quan đến tử
vong ở bệnh nhân ho gà nặng thở máy tại khoa
điều trị tích cực Bệnh viện Nhi Trung ương, Luận
án tiến sỹ, Trường Đại học Y Hà Nội, 2020.
[3] La C, Fm M, Clinical characteristics and
outcomes of neonatal pertussis: a comparative
study. The Journal of pediatrics, 156(3), 2010.
[4] Nieves DJ, Singh J, Ashouri N et al., Clinical and
laboratory features of pertussis in infants at the
onset of a California epidemic. J Pediatr, 159(6),
2011, 1044–1046.
[5] Cortese MM, Baughman AL, Zhang R et al.,
Pertussis hospitalizations among infants in the
United States, 1993 to 2004. Pediatrics, 121(3),
2008, 484–492.
[6] Đỗ Thị Thúy Nga, Hoàng Thị Thu Hà, Dương
Thị Hồng, Hiệu quả điều trị bệnh ho gà ở trẻ em
tại Bệnh viện Nhi Trung ương; Tạp chí Y học Dự
phòng, 5(178), 2016, 57–62.
[7] Yeung KHT, Duclos P, Nelson EAS et al., An
update of the global burden of pertussis in
children younger than 5 years: a modelling study.
The Lancet Infectious Diseases, 17(9), 2017,
974–980.
[8] Nieto Guevara J, Luciani K, Montesdeoca Melián
A et al., Hospitalizaciones por Bordetella pertussis:
experiencia del Hospital del Niño de Panamá,
periodo 2001–2008. Anales de Pediatría, 72(3),
2010, 172–178.
[9] Surridge J, Segedin ER, Grant CC, Pertussis
requiring intensive care. Arch Dis Child, 92(11),
2007, 970–975.