43. CLINICAL CHARACTERISTICS AND ASSOCIATED FACTORS OF FUNGAL NAIL INFECTION AT THE NATIONAL HOSPITAL OF DERMATOLOGY & VENEREOLOGY IN 2018

Do Thi Thu Hien1, Nguyen Thi Thu Nhien2, Hoang Hong Manh3
1 National Hospital of Dermatology and Venereology
2 Bac Thang Long Hospital
3 VNU University of Medicine and Pharmacy

Main Article Content

Abstract

Objective: To examine the clinical characteristics of fungal nail infection and related factors among patients from the National Hospital of Dermatology and Venereology in 2018.


Methods: Cross-sectional descriptive study on 110 patients with diagnosis of fungal nail infection by positive fungal culture at the National Hospital of Dermatology & Venereology from August 2018 to July 2019.


Results: The age group affected mostly by the disease is working age group of 20-59 years old, accounting for 70%, in which women accounted 61.3%. The proportion of patients living in rural areas is 2.66 times higher than the proportion of patients living in urban areas. Common occupations affected by the disease included manual workers such as farmers, people in contact with pets, livestock, or poultry (38.2%) and workers working frequently in wet environments (19.1%). The most common clinical manifestation was distal and lateral subungual onychomycosis, accounting for (71/110, 64.5%), followed by proximal subungual onychomycosis (48/110, 43.6%) and superficial white onychomycosis (38/110, 34.5%). The lesion with crumbly subungual hyper-keratosis was mainly observed, accounting for (53/110, 48,2%). Among 110 patients with positive fungal culture, 96 patients (87.3%) had positive KOH examination and 14 patients (12.7%) patients had negative KOH examination.


Conclusion: Fungal nail infection was common in people of working age, especially those worked in humid environments. The most common clinical manifestations were distal and lateral subungual onychomycosis and crumbly subungual hyperkeratosis. Eighty-seven point three percent of patients had similar results between KOH examination and culture, showing the high reliability of KOH examination in diagnosing fungal nail infection.

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References

[1] Gupta AK et al., Update on current approaches
to diagnosis and treatment of onychomycosis.
Expert Review of Anti-Infective Therapy, 2018.
16(12): p. 929-938.
[2] Lê Hữu Doanh, Bệnh học Da liễu. 2 ed. Vol. 1.
2019: Nhà xuất bản Y học. 293-311.
[3] Nguyễn Thị Đào, Nguyễn Đức Thảo, Bóc tách
móng bằng Ure-plaste kết hợp với Griseofulvine
trong điều trị nấm món. Nội san Da liễu, 1978:
p. 45-50.
[4] Gupta AK et al., Prevalence and epidemiology of
onychomycosis in patients visiting physicians’
offices: a multicenter canadian survey of 15,000
patients. Journal of the American Academy of
Dermatology, 2000. 43(2 Pt 1): p. 244-248.
[5] Bongomin F et al., A Review of Onychomycosis
Due to Aspergillus Species. Mycopathologia,
2018. 183(3): p. 485-493.
[6] Kim DM, MK Suh, GY Ha, Onychomycosis in
Children: An Experience of 59 Cases. Annals of
Dermatology, 2013. 25(3): p. 327-334.
[7] Aghamirian MR, SA Ghiasian, Onychomycosis
in Iran: epidemiology, causative agents and
clinical features. Nihon Ishinkin Gakkai Zasshi
= Japanese Journal of Medical Mycology, 2010.
51(1): p. 23-29.
[8] Ghannoum MA et al., A large-scale North
American study of fungal isolates from nails: the
frequency of onychomycosis, fungal distribution,
and antifungal susceptibility patterns. Journal of
the American Academy of Dermatology, 2000.
43(4): p. 641-648.
[9] Nickerson WJ, L Irving, HE Mehmert, Sandals,
and hygiene and infections of the feet. Archives
of Dermatology and Syphilology, 1945. 52: p.
365-368.
[10] Huang CC, PL Sun, Superficial white
onychomycosis caused by Trichophyton
verrucosum. International Journal of
Dermatology, 2008. 47(11): p. 1162-1164.