SITUATION OF DRUGS FOR TREATMENT INTESTINAL INFECTION

Lam Hoang Khanh1, Nguyen Huu Phuc1, Bui Tung Hiep2, Bui Dang Minh Tri2
1 Tay Do University
2 University of Medicine Pham Ngoc Thach

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Abstract

Objective: To survey the use of drugs to treat intestinal infection at Can Tho Children’s Hospital. Objects and methods: Cross-sectional retrospective descriptive study on 400 medical records of pediatric patients diagnosed with intestinal infection in Can Tho City Children’s Hospital in 2019. Result: There were 353 pediatric patients using rehydration and electrolytes measeurement, ORS with the highest frequency was 38.66%. The antibiotic with the highest frequency of use was the beta-lactam 3rd group. In which, Cefotaxim had the most use frequency. Single regimen of cefotaxim used the most with a frequency of 70.06%. Meanwhile, the antibiotic regimen cefotaxime combined with tobramycin was the highest in the combined regimen with 57.14%. Up to 70 cases changed the regimen due to ineffective results and 22 cases changed the regimen due to its effectiveness, reducing the amount of antibiotics. The first regimen with the highest frequency of change was the cefotaxim regimen with 33 cases. The 2nd regimens changed with the highest frequency were cefotaxim regimen and regimen of cefotaxim combined with tobramycin with 5 cases. The third change of regimen was mostly from combination antibiotic regimen to single regimen. Conclusion: Rehydration and electrolyte measures were mainly ORS. Antibiotics used mainly in the beta-lactam 3rd group, Cefotaxim had the highest frequency of use. Cefotaxim was used the most frequency in a single regimen. The antibiotic combined regimen between cefotaxime and tobramycin was the highest use in all combined regimens. Changing treatment regimen was mainly due to the ineffective effect.

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References

1. Mokomane M, Kasvosve I, De Meol E et al., The global problem of childhood diarrhoeal diseases: emerging strategies in prevention and management. Ther Adv Infect Dis. 2018; 5(1): 29-43.
2. Roth GA, Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017, The Lancet, 2018; 392(10159): 1736–1788.
3. Ho Chi Minh City Department of Health, Instructions for the use of antibiotics in hospitals, Medical Publishing House, 2018. (in Vietnamese)
4. Julie GI, Jennifer FA, Estes MK et al., Human mini-guts: new insights into intestinal physiology and host–pathogen interactions, Nat Rev Gastroenterol Hepatol, 2016; 13(11): 633.
5. Shane Al, Mody RK, Crump JA et al., 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea, Clin Infect Dis., 2017; 65(12): e45–e80.
6. Crawford SE, Rotavirus infection. Nat Rev Dis Primers, 2017; 13: 17083.
7. Koestler BJWC, Human Intestinal Enteroids as a Model System of Shigella Pathogenesis, Infect Immun, 2019; 87(4): 00733-18.
8. Sophie CW, Emma B, Clare N, Non-typhoidal Salmonella infections in children: Review of literature and recommendations for management, J Paediatr Child Health, 2017; 53(10): 936-941.
9. Tack B, Vanaenrode J, Verbakel JY et al., Invasive non-typhoidal Salmonella infections in sub-Saharan Africa: a systematic review on antimicrobial resistance and treatment, BMC Med., 2020; 18(1): 212.