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Published: 2026-06-29
Abstract Views: 11
DOI: https://doi.org/10.52163/yhc.v67iCD7.5596
Issue
Vol. 67 No. CĐ7- Trường ĐH Y Dược Hải Phòng
Section
Articles
How to Cite
Hùng, N. D., Hùng, T. Q., & Lộc, P. T. (2026). PREDICTIVE VALUE OF D-DIMER FOR THROMBOSIS, DISEASE STAGE, AND METASTASIS IN CANCER PATIENTS ACROSS ORGAN SYSTEMS. Vietnam Journal of Community Medicine, 67(CĐ7- Trường ĐH Y Dược Hải Phòng). https://doi.org/10.52163/yhc.v67iCD7.5596

PREDICTIVE VALUE OF D-DIMER FOR THROMBOSIS, DISEASE STAGE, AND METASTASIS IN CANCER PATIENTS ACROSS ORGAN SYSTEMS

Nguyen Duy Hung1, Tran Quang Hung2, Pham Thi Loc1
1 Hai Phong University of Medicine and Pharmacy, Vietnam
2 Viet Tiep Friendship Hospital, Hai Phong, Vietnam

Main Article Content

Abstract

Objective: To evaluate the value of D-dimer in predicting thrombosis, disease stage and metastasis across cancer organ systems.


Subjects and methods: A descriptive, cross-sectional analytical study on 557 cancer patients who underwent D-dimer testing from January 2024 to January 2026. Diagnostic value was assessed using ROC curves and area under the curve (AUC).


Results: The majority of patients were diagnosed at a late stage, particularly esophageal (97.14%), gastric (93.1%) and lung cancer (91.26%). Metastasis rates were highest in respiratory (70.48%), digestive (61.8%) and reproductive cancers (60.27%). The overall thrombosis rate was 14%, highest in renal-urinary (22.22%), digestive (21.35%). D-dimer was elevated in most cancer groups and significantly higher in patients with thrombosis. D-dimer showed the best predictive value in reproductive cancers (AUC for late stage = 0.8147; thrombosis = 0.7104), followed by respiratory cancers, moderate in digestive cancers and lowest in head and neck cancers.


Conclusion: D-dimer has predictive value for thrombosis and disease progression in cancer patients, particularly in reproductive cancers. Predictive performance varies across organ systems, suggesting a potential role for individualized use of D-dimer in risk assessment and monitoring of cancer patients.

Article Details

Keywords

D-dimer, thrombosis, disease stage, metastasis, cancer.

References

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