THE EFFECT OF PSYCHOTROPIC DRUGS ON WEIGHT IN ELDERLY INPATIENTS AT NATIONAL GERIATRIC HOSPITAL
Main Article Content
Abstract
Background: Psychotropic drugs, including antipsychotics and antidepressants, have been found to have a significant weight-gaining effect.
Objectives: To evaluate the impact of several psychotropic drugs on the weight of elderly patients with mental disorders inpatients at the Department of Mental Health, National Geriatric Hospital.
Method: A descriptive, prospective study was conducted, including 31 inpatients at the Department of Mental Health, National Geriatric Hospital from April 2019 to January 2020. Anthropometric measurements were taken at admission, after 1 week, after 2 weeks, after 3 weeks, and after 4 weeks.
Results: The most frequently used drugs included antidepressants such as mirtazapine (51.6%) and paroxetine (22.6%). Antipsychotic drugs such as sulpiride (38.7%), quetiapine (25.8%), olanzapine (22.6%), and risperidone (16.1%) were used. The majority of patients gained less than 7% of their body weight after treatment; no patients gained more than 7% of their body weight during treatment. After two weeks, the patients' weight increased significantly, with an average increase of 0.97 kg (SD=0.8; p=0.001). Follow-up after 2 weeks showed a significant reduction in the number and proportion of patients experiencing appetite problems.
Conclusion: Elderly patients using antipsychotic drugs showed significant improvement in appetite and weight gain.
Article Details
Keywords
elderly, psychotropic drugs, antidepressants, antipsychotics, weight-gain.
References
2. Umbricht DS, Pollack S, Kane JM. Clozapine and weight gain. The Journal of clinical psychiatry. Sep 1994. 55 Suppl B:157-160.
3. Bean MK, Stewart K, Olbrisch ME. Obesity in America: implications for clinical and health psychologists. Journal of clinical psychology in medical settings. Sep 2008. 15(3):214-224. doi:10.1007/s10880-008-9124-9.
4. Nasrallah H. A review of the effect of atypical antipsychotics on weight. Psychoneuroendocrinology. Jan 2003. 28 Suppl 1:83-96. doi:10.1016/s0306-4530(02)00114-2.
5. Musil R, Obermeier M, Russ P, Hamerle M. Weight gain and antipsychotics: a drug safety review. Expert opinion on drug safety. Jan 2015. 14(1):73-96. doi:10.1517/14740338.2015.974549.
6. Hasnain M, Vieweg WV. Weight considerations in psychotropic drug prescribing and switching. Postgraduate medicine. Sep 2013. 125(5):117-129. doi:10.3810/pgm.2013.09.2706.
7. Allison DB, Mentore JL, Heo M, et al. Antipsychotic-induced weight gain: a comprehensive research synthesis. The American journal of psychiatry. Nov 1999. 156(11):1686-1696. doi:10.1176/ajp.156.11.1686.
8. Choong E, Bondolfi G, Etter M, et al. Psychotropic drug-induced weight gain and other metabolic complications in a Swiss psychiatric population. Journal of psychiatric research. Apr 2012. 46(4):540-548. doi:10.1016/j.jpsychires.2012.01.014.
9. Yeung EY, Chun S, Douglass A, Lau TE. Effect of atypical antipsychotics on body weight in geriatric psychiatric inpatients. SAGE open medicine. 2017. 5:2050312117708711. doi:10.1177/2050312117708711.
10. Kinon BJ, Kaiser CJ, Ahmed S, Rotelli MD, Kollack-Walker S. Association between early and rapid weight gain and change in weight over one year of olanzapine therapy in patients with schizophrenia and related disorders. Journal of clinical psychopharmacology. Jun 2005. 25(3):255-258. doi:10.1097/01.jcp.0000161501.65890.22.