Article Sidebar

Published: 2026-04-02
Abstract Views: 0
DOI: https://doi.org/10.52163/yhc.v67iCD3.4771
Issue
Tập 67 Số CĐ3-NCKH
Section
Articles
How to Cite
Sinh, Đoàn X., Chi, T. T. L., Hạnh, V. T., Hạnh, N. Đức, & Quý, T. V. (2026). DIAGNOSTIC VALUE OF COMPUTED TOMOGRAPHY IN PEDIATRIC WILMS TUMOR. Vietnam Journal of Community Medicine, 67(CD3). https://doi.org/10.52163/yhc.v67iCD3.4771

DIAGNOSTIC VALUE OF COMPUTED TOMOGRAPHY IN PEDIATRIC WILMS TUMOR

Doan Xuan Sinh1, Tran Thi Linh Chi1, Vu Thi Hanh1, Nguyen Duc Hanh2, Tran Van Quy1
1 Vinmec Hai Phong International General Hospital
2 Office of the Minister, Ministry of Health

Main Article Content

Abstract

Objective: To evaluate the diagnostic value of Computed Tomography (CT) in children with nephroblastoma (Wilms tumor).


Materials and Methods: A descriptive study was conducted on 43 children under 15 years of age, including 32 patients with nephroblastoma and 11 with other malignant renal tumors, treated at the National Children’s Hospital from August 2023 to July 2024. Post-surgical histopathological results were obtained for all cases to serve as the gold standard.


Results: The majority of patients were under 60 months old (range: 9 months to 10 years), with an equal gender distribution. Common clinical presentations included a palpable abdominal mass (75%) and hematuria (34.4%). The mean tumor size was 8.4 cm, with 84.4% of cases measuring >5 cm. CT findings showed that most tumors had well-defined margins (75%), heterogeneous density (65.6%), marked enhancement (75%), and necrosis (68.75%). Intratumoral calcification was absent in 87.5%, and hemorrhage was present in only 18.7%. Among CT signs, intratumoral calcification and the presence of a pseudocapsule yielded the highest diagnostic value (83.7%), while alteration of the renal contour had the lowest (65.1%). The three features with the highest sensitivity were the pseudocapsule sign, necrosis/hemorrhage, and intratumoral calcification. The three features with the highest specificity were the pseudocapsule sign, intratumoral calcification, and tumor margins.


Conclusion: CT imaging is highly effective in diagnosing nephroblastoma and differentiating it from other pediatric tumors.

Article Details

Keywords

Computed Tomography (CT), nephroblastoma, Wilms tumor, pediatric.

References

1. Artunduaga M, Eklund M, van der Beek JN, et al. (2023). Imaging of pediatric renal tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper focused on Wilms tumor and nephrogenic rests. Pediatr Blood Cancer, 70 Suppl 4(Suppl 4), e30004.
2. Phó Hồng Điệp, Hoàng Ngọc Thạch, Bùi Ngọc Lan (2024). Đặc điểm u thận trẻ em tại Bệnh viện Nhi Trung Ương (2017-2022). Tạp chí Nhi khoa, 17(5), 41-46.
3. Mai Tấn Liên Bang, Trần Công Đoàn, Huỳnh Quang Huy (2018). Nghiên cứu giá trị Xquang cắt lớp vi tính trong đánh giá xâm lấn của u Wilms ở trẻ em. Tạp chí Y học TP Hồ Chí Minh, 22(3), 95-100.
4. Chandola S, Naranje P, Gupta AK, et al. (2026). CT-Based Texture Analysis in Indeterminate Pediatric Renal and Pararenal Masses. Indian J Radiol Imaging, 36(1), 76-83.
5. Koska IO, Ozcan HN, Tan AA, et al. (2024). Radiomics in differential diagnosis of Wilms tumor and neuroblastoma with adrenal location in children. Eur Radiol, 34(8), 5016-5027.
6. Reiman TA, Siegel MJ, Shackelford GD (1986). Wilms tumor in children: abdominal CT and US evaluation. Radiology, 160(2), 501-505.
7. Lowe RE, Cohen MD (1984). Computed tomographic evaluation of Wilms tumor and neuroblastoma. Radiographics, 4(6), 915-928.
8. Bùi Ngọc Lan, Nghiêm Ngọc Linh (2025). Kết quả điều trị u nguyên bào thận theo phác đồ SIOP tại Bệnh viện Nhi Trung Ương. Tạp chí Nghiên cứu Y học, 191(6), 589-595.
9. Benedetti DJ, Cost NG, Ehrlich PF, et al. (2025). Updated favourable-histology Wilms tumour risk stratification: rationale for future Children’s Oncology Group clinical trials. Nature Reviews Urology, 22(11), 775-788.