EVALUATION OF THE RELATIONSHIP BETWEEN PREOPERATIVE INTAKE OF A CARBOHYDRATE-RICH SOLUTION AND GASTRIC RESIDUAL VOLUME, CHANGES IN BLOOD GLUCOSE LEVELS, SERUM ELECTROLYTE CONCENTRATIONS, AND THE INCIDENCE OF NAUSEA AND VOMITING IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANESTHESIA AT HAI PHONG OBSTETRICS AND GYNECOLOGY HOSPITAL IN 2025

Pham Thi Anh Tu1, Dao Van Tung2, Bui Van Tung1
1 Hai Phong hospital of Obstetrics and Gyencology
2 Hai Phong Medical College

Main Article Content

Abstract

Objective: This prospective randomized controlled study evaluated the effects of drinking a carbohydrate-rich solution 2 hours before surgery on gastric residual volume, blood glucose levels, serum electrolytes, and postoperative nausea and vomiting in patients undergoing open surgery under general anesthesia at Hai Phong hospital of Obstetrics and Gynecology.  


Subjects and Methods: 80 patients were enrolled after screening and randomly assigned to two groups of 40 patients each: a complete fasting group following the Ministry of Health guidelines and a carbohydrate group receiving a carbohydrate-rich drink 2 hours before surgery.


Results: The mean gastric residual volume was 8.3 ± 7.6 ml in the fasting group and 7.5 ± 8.2 ml in the carbohydrate group, with no statistically significant difference (p > 0.05), and no cases of gastric regurgitation were observed during anesthesia induction. Mean venous blood glucose levels at 30 minutes after induction and 2 hours after recovery were comparable between groups and showed no significant differences (p > 0.05). The incidence of nausea and vomiting before surgery and at 2 hours after recovery was low in both groups, with no significant differences. Serum electrolyte concentrations (Na⁺, K⁺, Cl⁻) measured before anesthesia and 2 hours after recovery remained within normal physiological ranges in both groups and did not differ significantly (p > 0.05).


Conclusion: These findings indicate that administration of a carbohydrate-rich solution 2 hours before surgery is safe and effective, without increasing gastric residual volume, causing significant hyperglycemia, electrolyte imbalance, or increasing postoperative nausea and vomiting.

Article Details

References

1. Xu, D., et al., Shortened preoperative fasting for prevention of complications associated with laparoscopic cholecystectomy: a meta-analysis. Journal of International Medical Research, 2017. 45(1): p. 22-37.
2. Đỗ Nguyễn Trọng Nhân và Nguyễn Thị Thanh, Đánh giá thể tích tồn lưu dạ dày của dung dịch maltodextrin 25% uống 2 giờ trước gây mê. Tạp chí Y dược thành phố Hồ Chí Minh, 2020. 24(3): p. 119-126.
3. Yuill, K.A., et al., The administration of an oral carbohydrate-containing fluid prior to major elective upper-gastrointestinal surgery preserves skeletal muscle mass postoperatively-a randomised clinical trial. Clinical Nutrition, 2005. 24(1): p. 32-37.
4. Bộ Y tế, Quyết định số 181/QĐ-BYT ngày 23 tháng 01 năm 2024 về việc ban hành Hướng dẫn nhịn ăn uống và cung cấp carbohydrate trước phẫu thuật chương trình. 2024.
5. Nygren, J., A. Thorell, and O. Ljungqvist, Preoperative oral carbohydrate nutrition: an update. Current Opinion in Clinical Nutrition & Metabolic Care, 2001. 4(4): p. 255-259.
6. Hausel, J., et al., A carbohydrate-rich drink reduces preoperative discomfort in elective surgery patients. Anesthesia & Analgesia, 2001. 93(5): p. 1344-1350.
7. Yildiz, H., et al., Oral carbohydrate supplementation reduces preoperative discomfort in laparoscopic cholecystectomy. Journal of Investigative Surgery, 2013. 26(2): p. 89-95.
8. Bilku, D.K., et al., Role of preoperative carbohydrate loading: a systematic review. Ann R Coll Surg Engl, 2014. 96(1): p. 15-22.