30. EVALUATION OF RESULTS AFTER TRANSURETHRAL ENDOSCOPIC SURGERY FOR ADVANCED PROSTATE CANCER WITH BIDUAL ORCHECTOMY AT VIET DUC HOSPITAL FROM 1/2018 - 12/2022

Tran Quang Hung1, To Thanh Dong2, Vu Thu Hoai2, Do Truong Thanh3
1 Department of Surgery - Central Traditional Medicine Hospital
2 Department of Mathematics and Information Technology - Hanoi Medical University
3 Department of Urology - Viet Duc Hospital

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Abstract

Abstract: The study aimed to evaluate the results after transurethral endoscopic resection of advanced prostate cancer with bilateral orchiectomy at Viet Duc Hospital from January 2018 to December 2022.


Subjects and methods: The retrospective method followed up longitudinally on 217 patients diagnosed with advanced prostate cancer who underwent transurethral resection of the tumor with bilateral orchiectomy.


Results: Most of the patients were in stages T3, T4 accounting for 82.9%, early stage T2 accounting for only 17.1%. Of the 217 patients, 118 were alive (54.4%), 99 patients (45.6%) died. The survival rate decreased gradually over the follow-up time of the groups from 24 to 72 months after surgery, corresponding to 67.1% to 36.8%. The main cause of death was cancer metastasis to other organs. Factors affecting survival rate and overall survival time were Gleason score, age group and stage of  Prostate cancer  (p<0.05). The ability to urinate and the quality of life of patients improved significantly after surgery: according to the IPSS scale, the majority of postoperative patients at the time of re-examination - interview had mild and moderate urinary disorders, accounting for 94.1%, much higher than the pre-operative level of 36.5% (p<0.001). The quality of life (QoL) of postoperative patients was at an acceptable and satisfactory level of 90.6%, higher than the pre-operative level of 18.5% (p<0.001).

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References

[1]. Deo S., Sharma J., Kumar S. (2022). GLOBOCAN 2020 Report on Global Cancer Burden: Challenges and Opportunities for Surgical Oncologists., Ann Surg Oncol, 29(11), p6497-6500.

[2]. WHO (2020). GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J Clin, 2021 Feb 4.

[3]. Rebecca L., Kimberly D., Hannah E., et al (2022). Cancer statistics, 2022, CA: A Cancer Journal for Clinicians, 72, p7-33.

[4]. WHO (2021). The Global Cancer Observatoty: Viet Nam, Int J Cancer,

[5]. Dong Van Hoang, Ngoc Minh Pham (2018). Dietary Carotenoid Intakes and Prostate Cancer Risk: A Case-Control Study from Vietnam, Nutrients, 10(1), 70.

[6]. Humphrey A. (2004). Gleason grading and prognostic factors in carcinoma of the prostate, Modern Pathology, 17, 292–306.

[7]. Fang K., Song P., Zhang J., et al (2021). The Impact of Palliative Transurethral Resection of the Prostate on the Prognosis of Patients With Bladder Outlet Obstruction and Metastatic Prostate Cancer: A Population-Matched Study, Front Surg, 8, Oct 29:8:726534.

[8]. Huggins C., Hodges C. (1941). Studies on Prostatic Cancer: The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate, Cancer research, 1(4), 293.

[9]. Bubendorf L. (2000). Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients, Hum Pathol, 31(5), p578-583.

[10]. Tremont-Lukats, Bobustuc G., Lagos G., et al (2003). Brain metastasis from prostate carcinoma: The M. D. Anderson Cancer Center experience, Cancer, 98(2), p363-368.

[11]. Lê Thị Khánh Tâm (2020). Đánh giá kết quả điều trị nội tiết ung thư tuyến tiền liệt giai đoạn IV, Luận văn Tiến sĩ, Đại học Y Hà Nội.
[12]. Nguyễn Duy Điền, Trần Ngọc Sinh, Thái Minh Sâm (2011). Cắt đốt nội soi tạo đường hầm trên bệnh nhân bí tiểu do ung thư tuyến tiền liệt, Y Học TP. Hồ Chí Minh, 15 (3), 14-18.

[13]. Đào Trọng Đại (2020). Kết quả phẫu thuật nội soi qua niệu đạo cắt ung thư tuyến tiền liệt giai đoạn tiến triển kèm cắt tinh hoàn hai bên ở bệnh viện Hữu nghị Việt Đức, Luận văn Thạc sĩ, Đại học Y Hà Nội.

[14]. Stamey T., Mc Neal J. (1992). Adenocarcinoma of the prostate, Campbell’s Urology, 6, 1159-1214.

[15]. Albertsen P., Moore D., Shih W., et al (2011). Impact of Comorbidity on Survival Among Men With Localized Prostate Cancer, Journal of Clinical Oncology, 29(10), 1335-1341.