Article Sidebar

PDF (Tiếng Việt)
Published: 2025-03-04
Abstract Views: 21
Views PDF (Tiếng Việt): 7
DOI: https://doi.org/10.52163/yhc.v66i2.2051
Issue
Vol. 66 No. 2
Section
Articles
How to Cite
Truyền, C. Q. ., Nghĩa, Đỗ C. T., Phượng, Đặng N., Trang, N. T. T., Thảo, Đỗ T., Mạnh, L. H., Thanh, T. V., Cảnh, V. V., Vân, Đinh T., Quỳnh, L. P. ., & Ính, C. T. (2025). 7. STUDY IN ACUTE TOXICITY AND SUB-CHRONIC TOXICITY OF RAW MATERIALS FOR PRODUCING JASMIN DETOX HARD CAPSULES ON EXPERIMENTAL ANIMALS. Vietnam Journal of Community Medicine, 66(2). https://doi.org/10.52163/yhc.v66i2.2051

7. STUDY IN ACUTE TOXICITY AND SUB-CHRONIC TOXICITY OF RAW MATERIALS FOR PRODUCING JASMIN DETOX HARD CAPSULES ON EXPERIMENTAL ANIMALS

Chu Quang Truyen1, Do Cong Tuan Nghia2, Dang Ngoc Phuong2, Nguyen Thi Thuy Trang2, Do Thi Thao3, Le Hong Manh4, Tran Van Thanh5, Vo Van Canh6, Dinh Thi Van7, Le Phuong Quynh1, Cam Thi Inh1
1 Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
2 institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
3 Institute of Biotechnology, Vietnam Academy of Science and Technology
4 Institute of Physics - Vietnam Academy of Science and Technology
5 Vietnam University of Traditional Medicine
6 National Institute of Hematology and Blood Transfusion
7 Faculty of Pharmacy, Hanoi University of Business and Technology

Main Article Content

Abstract

The toxicity of material M1 used for production of Jasmin detox, a dietary supplement containing powdered Jasminum subtriplinerve, Silybum marianum, Centella asiatica, Solanum procumbens, and Cynara scolymus as main ingredients, has been evaluated in acute and sub-chronic toxicity studies. Acute oral toxicity studies in ICR mice did not detect mortality or treatment-related signs at a dose of 5000 mg/kg/24h for 72h (LD50 >5000 mg/kg). Dose selection for sub-chronic toxicity studies of LD50 (500 mg/kg). After continuous administration of M1 for 28 days at this dose, treated mice presented no significant change in body weight, in daily behaviors and weight of selected organs (liver, spleen, and kidney) as well. The hematological parameters, liver indices (ALT level), renal indices (creatinine level) were not affected. The study showed that materials to produce Jasmin detox capsules are safe to be taken orally at a dose of 500 mg/kg bd.w for 28 days.

Article Details

Keywords

Chevang, acute toxicity, sub-chronic toxicity, hematological parameters

References

[1] “Hướng dẫn thử nghiệm tiền lâm sàng và lâm sàng thuốc đông y, thuốc từ dược liệu” của Bộ y tế ban hành theo quyết định số 141/QĐ-K2ĐT ngày 27 tháng 10 năm 2015.
[2] OECD (Organization for Economic Cooperation and Development) (2008). OECD guidelinesfor testing of chemicals. Section 4, health effects: Test No. 425: Acute oral toxicity: Up–and–down procedure.
[3] OECD (Organization for Economic Cooperation and Development) (2001). OECD guidelinesfor testing of chemicals. Section 4, health effects: Test No. 420: Acute oral toxicity - Fixed Dose Procedure.
[4] Akhila JS, Deepa S, Alwar MC (2007) Acute toxicity studies and determination of median lethal dose. Curr Sci, 93: 917-920.
[5] TrM4re A, Sylvin OuedrM4go, Adama Kabore, Hamidou H Tamboura and I Pierre Guissou (2014) The acute toxicity in mice and the in vitro anthelminthic effects on Haemonchus contortus of the extracts from three plants (Cassia ieberiana, Guiera senegalensis and Sapium grahamii) used in traditional medicine in Burkina Faso. Annals of Biological Research, 5 (2):41-46