SAFETY OF STANDARDISED SHORTER REGIMENS FOR MULTIDRUG-RESISTANT TUBERCULOSIS IN HANOI LUNG HOSPITAL

Abstract

Objectives: The study demonstrated the clinical
symtoms of patients with multidrug-resistant tuberculosis
(MDR-TB) and addressed the safety of standardised,
shorter MDR-TB regimens
Methods: The cohort study was conducted with
124 patients with MDR-TB. All patients were treated by
standardised, shorter MDR-TB regimens in Hanoi Lung
Hospital from April 2016 to December 2018.
Results: Sputum smear results were 47,6% AFB (-),
5.6% AFB(3+), 7.3% AFB (2+), 35.5% AFB (1+) and
4.0% 1-9 AFB/100VT. Radiological signs were 70.2%
fbrosis, 67,7% node, 56,6% infliltrate and 16.9% cavity.
62.9% patients had lesions in both lungs. Safety ratio
was 58.9%. Adverse events were 10.5% dyspepsia, 8.9%
vomiting, 8.9% dizzy, 8.1% anorexia, 4.8% athritis and
4.3% hearing loss.
Conclusion: The standardised, shorter MDR-TB
regimens was safety with less adverse events. All of
the side effect symptoms had recovered after fnishing
treatment.