15. STUDY ON FERRITIN CONCENTRATION AND RELATIONSHIP WITH SOME CLINICAL INDICATORS IN COVID-19 PATIENTS
Main Article Content
Abstract
Objective: Determine ferritin concentration according to disease severity and relationship with some clinical indicators in COVID-19 patients.
Subject and method: From February 2022 - April 2023; at the Department of Biochemistry, Covid Center - Military Hospital 103; Cross-sectional description study method using forf 155 COVID-19 patients (50 mild patients, 70 moderate patients, 35 severe patients) who fully met research criteria.
Results: Ferritin concentration in study subjects with mild disease was 293.45 ng/ml, average level was 421.19 ng/ml, severe level was 794.35 ng/ml, differences between disease levels were significant. statistical significance with p < 0.001; The proportion of patients with increased ferritin compared to the reference value (0-300 ng/mL) gradually increases with disease severity (mild severity group is 44%, moderate severity group is 61.43%, severe severity group is 77.14 %), ferritin concentration is related to disease severity with p < 0.05; The ferritin threshold that differentiates mild-moderate patients is 150.6 ng/mL (AUC = 0.678) and the ferritin threshold that differentiates severe patients is 446.08 ng/mL (AUC = 0.668); Ferritin concentration has a moderate positive relationship with age (r = 0.308, p < 0.05), gender (r = 0.352, p = 0.000) and disease severity (r = 0.352, p = 0.000); In the severe group, Ferritin concentration had a moderate positive relationship with breathing frequency (r = 0.367, p = 0.03), with no relationship with SpO2.
Conclusion: Ferritin concentrations in research subjects gradually increased and were related to disease severity; Ferritin concentration has a moderate positive relationship with age, gender and disease severity; Ferritin concentration has a moderate positive relationship with breathing frequency in the severe group.
Article Details
Keywords
Ferritin, Covid-19.
References
2019.
[2] Statsenko Y, Al Zahmi F, Habuza T et al.,
Prediction of COVID-19 severity using
laboratory findings on admission: informative
values, thresholds, ML model performance. BMJ
Open, 2021;11:e044500.
[3] Kermali M, Khalsa RK, Pillai K et al., The role
of biomarkers in diagnosis of COVID-19–A
systematic review; Life Sci, 2020; 254:117788.
[4] Kurosu H, Yamamoto M, Clark JD et al.,
Suppression of aging in mice by the hormone
Klotho. Science (New York, NY), 2005;
309(5742):1829-33.
[5] Chen X, Zheng L, Ye S et al., Research on
Influencing Factors and Classification of Patients
With Mild and Severe COVID-19 Symptoms;
Front Cell Infect Microbiol, 2021;11:670823.
[6] Takahashi T, Ellingson MK, Wong P et al., Sex
differences in immune responses that underlie
COVID-19 disease outcomes. Nature, 2020;
588, 315–320.
[7] Pagano MT, Peruzzu D, Ruggieri A, al. e,
Vitamin D and Sex Differences in COVID-19;
Front Endocrinol (Lausanne), 2020;11:567824.
[8] Wray S, S. A, The Physiological Mechanisms
of the Sex-Based Difference in Outcomes
of COVID19 Infection. Front Physiol, 2021;12:627260.
[9] Li Q, Liu X, Li L et al., Comparison of clinical
characteristics between SARS-CoV-2 Omicron
variant and Delta variant infections in China.
Front Med (Lausanne), 2022;9:944909.
[10] Jayaswal SK, Singh S, Malik PS et al., Detrimental
effect of diabetes and hypertension on the severity
and mortality of COVID-19 infection: A multicenter
case-control study from India. Diabetes
Metab Syndr, 2021;15(5):102248.
[11] Chatterjee NA, Jensen PN, Harris AW et al.,
Admission respiratory status predicts mortality
in COVID-19. Influenza Other Respir Viruses,
2021;15(5):569-72.
[12] Maghfirah AI, Esa T, Y W et al., Correlationof-
serum-ferritin-levels-and-covid19-severityin-
makassar. Journal of Microbiology and
Immunology, 2022;Vol.4, Issue 1, 1-5.
[13] Feld J, Tremblay D, Thibaud S et al., Ferritin
levels in patients with COVID-19: A poor
predictor of mortality and hemophagocytic
lymphohistiocytosis. Int J Lab Hematol,
2020;42(6):773-9.
[14] Kaushal K, Kaur H, Sarma P et al., Serum
ferritin as a predictive biomarker in COVID-19.
A systematic review, meta-analysis and meta
regression analysis. J Crit Care, 2022;67:172-181.
[15] Al-Hatemy M, Mohsin M, D. A-R, The
correlation between Interleukin-6 and D-dimer,
Serum ferritin, CRP in COVID-19 patients. Kufa
Journal for Nursing Sciences, 12(1), 2022.
[16] Shital P, Gajanan G, Acharya A, “Serial ferritin
titer” monitoring in COVID-19 pneumonia:
valuable inflammatory marker in assessment of
severity and predicting early lung fibrosis —
prospective, multicentric, observational, and
interventional study in tertiary care setting in
India. The Egyptian Journal of Internal Medicine,
2022;34:75.