7. NGHIÊN CỨU BÀO CHẾ VIÊN NANG NHẤT GAN LINH

Abstract

Objectives: To prepare the Nhat Gan Linh capsules and evaluate the quality of the preparations.

Subjects and methods: Preparation of “Nhat gan linh” capsule including 15 medicinal herbs (Radix Glehniae, Radix Rehmanniae glutinosae, Radix Angelicae sinensis, Fructus Meliae toosendan, Polyporus, Poria, Radix Eurycomae longifoliae, Rhizoma Alismatis, Styli et stigmata Maydis, Cortex Phellodendri, Cortex Radicis Paeoniae suffruticosae, Fructus Corni officinalis, Fructus aurantii immaturus, Radix Bupleuri chinensis, Radix Paeoniae lactiflorae) via the wet grinding method and evaluation of capsule quality according to Vietnam Pharmacopoeia V.

Results: A formulation of Nhat gan linh capsule consisted of powdered extract Nhat gan linh 500mg, corn starch 35mg, sodium starchglycolate 35mg, magnesium tearat 10mg and Aerosil 4mg; preparation process included spray drying of extract, mixing, drying and encapsulation. The capsule prepared matched the quality requirements of Vietnam Pharmacopoeia V, including loss on drying, test for disintegration, uniformity of dosage units, qualitative and quantitative assay, heavy metals and microbial limit.

Conclusions: The “Nhat gan linh” capsules were prepared to support the treatment of cirrhosis, a scientific base for further in-depth studies to promote the value of traditional medicines.