27. DETERMINATION IN FULL-TERM NEWBORNS WITH SEPSIS AT VIETNAM NATIONAL CHILDREN’S HOSPITAL (2019 - 2021)
Main Article Content
Abstract
Objectives: The study was conducted to determine the role of the diagnosis of neonatal sepsis.
Methods: The study was designed using experimental, descriptive research method at the laboratory.
Results: Mean values of nCD64, mHLA-DR and SI in full-term newborns with sepsis were 10167.1 ± 6136.9 molecules/cell, 9898.4 ± 14173,9 molecules/cell, and 274.6 ± 287.5, respectively. SI and nCD64 had high values in the diagnosis of sepsis in full-term newborns (AUC = 0.8, p < 0.01), higher than that of CRP, platelets and white blood cells. The sensitivity and specificity of SI at the SI cut-off point > 29.1 were 95.1% and 41.2%, respectively. The sensitivity and specificity of nCD64 at the nCD64 cut-off point > 5004 were 88.2% and 44.5%, respectively.
Conclusions: SI and nCD64 are highly valuable in diagnosing sepsis in full-term newborns (AUC = 0.8, p < 0.01).
Article Details
Keywords
Sepsis, newborns.
References
spotlight on maternal and neonatal sepsis:World
Sepsis Day 2017.
world-sepsis-day/en/>, accessed:06/07/2021
[2] Pek JH, Yap BJ et al., Neurocognitive impairment
after neonatal sepsis: protocol for a systematic
review and meta-analysis. BMJ Open, 10(6),
2020, pp.125-132
[3] Ng PC, Li G, Chui KM et al., Neutrophil CD64
Is a Sensitive Diagnostic Marker for Early-Onset
Neonatal Infection. Pediatr Res, 56(5), 2004
pp.796–803.
[4] Genel F, Atlihan F, Ozsu E et al., Monocyte HLADR
expression as predictor of poor outcome in
neonates with late onset neonatal sepsis. Journal
of Infection, 60(3), 2010, pp. 224–228.
[5] Lê Hùng Phong, Trần Thanh Tùng, Lê Văn Hiệp,
Nghiên cứu chỉ số CD64 trên người bệnh nhiễm
trùng huyết tại Bệnh viện Chợ Rẫy; Tạp chí khoa
học Đại học Văn Lang; Số 21, Tháng 5, 2020,
Tr 70-75.
[6] Phạm Thị Ngọc Thảo, Nguyễn Lý Minh Duy và
CS, Đánh giá chỉ số nhiễm khuẩn huyết (tỷ số
CD64 trên bạch cầu đa nhân trung tính/HLADR
trên bạch cầu đơn nhân) trong nhiễm khuẩn
huyết, sốc nhiễm khuẩn; Tạp chí Y học Việt
Nam, 496, 2020, tr.555–563.
[7] Nguyễn Như Tân, Bùi Quốc Thắng, Đặc điểm
dịch tễ học, lâm sàng, cận lâm sàng và kết quả
điều trị nhiễm khuẩn huyết sơ sinh do klebsiella
spp. tại khối sơ sinh Bệnh viện Nhi Đồng 1
1/1/2008 đến 31/12/2009; Tạp chí Y học Thành
phố Hồ Chí Minh, 15(1); 2011, 52-58,
[8] Du J, Li L, Dou Y et al., Diagnostic Utility of
Neutrophil CD64 as a Marker for Early-Onset
Sepsis in Preterm Neonates. PLOS ONE, 9(7),
2014, pp.103-110.
[9] Manzoli TF, Troster EJ, Ferranti JF, Prolonged
suppression of monocytic human leukocyte
antigen-DR expression correlates with mortality
in pediatric septic patients in a pediatric tertiary
Intensive Care Unit. J Crit Care, Vol.33, 2017,pp.84–89.
[10] Meisel C, Schefold JC, Pschowski R et
al., Granulocyte-macrophage colonystimulating
factor to reverse sepsis-associated
immunosuppression: a double-blind, randomized,
placebo-controlled multicenter trial. Am J Respir
Crit Care Med, 180(7), 2009, pp.640–648.
[11] Tamulyte S, Kopplin J, Brenner T et al.,
Monocyte HLA-DR assessment by a novel pointof-
care device is feasible for early identification
of icu patients with complicated courses-a proofof-
principle study; Front Immunol, 10, 2019,pp.432 - 440.
[12] Goswami S, Gupta R, Ramji S, Flow Cytometry:
An Important Diagnostic Tool in Critically Ill
Preterm Neonates with Suspected Sepsis. Am J
Perinatol; 2020 Sep 29; pp.110-119
[13] Umlauf VN, Dreschers S, Orlikowsky TW,
Flow Cytometry in the Detection of Neonatal
Sepsis. International Journal of Pediatrics,
2013, pp.191 - 199
[14] Lam HS, Cheung HM, Poon TCW et al.,
Neutrophil CD64 for daily surveillance of
systemic infection and necrotizing enterocolitis
in preterm infants. Clin Chem, 59(12), 2013,
PP.1753–1760.