13. ANTIBIOTICS IN PEDIATRIC PATIENTS WITH ASTHMA
Main Article Content
Abstract
Objective: To survey the situation of antibiotic use in pediatric patients with asthma at Vinh Long Provincial General Hospital.
Subjects and methods: Cross-sectional descriptive study, 104 children diagnosed with asthma, inpatient treatment at Vinh Long Provincial General Hospital.
Results: In patients with asthma without superinfection, the majority of patients were prescribed antibiotics alone (92.5%). Meanwhile, in pediatric asthma with superinfection, more combination regimens were indicated (52.5%). In the monotherapy regimen, the most commonly used antibiotic was Ceftazidin. Besides, the combination regimen used was Ceftriazone + Macrolid and Ceftazidin + Macrolid. Among those with no evidence of infection, antibiotic use was associated with a longer hospital stay compared with the group who did not use antibiotics.
Conclusion: In patients with asthma without superinfection, the majority of patients were assigned to use antibiotics alone, pediatric patients with superinfected asthma mainly used combination regimens. In the single regimen, the most used antibiotic is Ceftazidin. The combination regimen usually uses Ceftriazone + Macrolid and Ceftazidin + Macrolid.
Article Details
Keywords
Antibiotics, Pediatric patients, Asthma.
References
153, 2007.
[2] Phan Hữu Nguyệt Diễm, Nguyễn Thanh Hải,
Tình hình sử dụng kháng sinh trên trẻ hen ở
Bệnh viện Nhi Đồng 1, Tạp chí Y học TP Hồ Chí
Minh, 2021.
[3] Jick SBM, Jick H, Arndt K, Drug-induced
cutaneous reactions. A report from the Boston
Collaborative Drug Surveillance Program on
15,438 consecutive inpatients, 1975 to 1982,
JAMA, 256: 3358–63, 1986.
[4] Fick DM, Stallworth LE, Ownby DR et al.,
Antibiotic use in children who have asthma:
results of retrospective database analysis, J
Manag Care Pharm, 11: 657–62, 2005.
[5] Sayer B, Normansell R, Waterson S et al.,
Antibiotics for exacerbations of asthma.
Cochrane Database Syst Rev, 6(6): CD002741,
2018.
[6] Long W, Tang J, Yan L et al., Procalcitonin
guided antibiotic therapy of acute exacerbations
of asthma: a randomized controlled trial, BMC
Infect Dis, 13(596), 2013.
[7] Li LJ, Long W, Huang GZ et al., Procalcitonin
guidance for reduction of antibiotic use in patients
hospitalized with severe acute exacerbations
of asthma: a randomized controlled study with
12-month follow-up, Crit Care, 18(5): 471, 2014.