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Published: 2023-08-23
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DOI: https://doi.org/10.52163/yhc.v64i5.768
Issue
Vol. 64 No. 5
Section
Articles
How to Cite
Trí, B. Đặng M. ., Út, K. V. ., & Tuyết, L. T. N. . (2023). 12. EFFICIENCY TREATMENT OF HYPOTENSION AFTER SPINAL ANESTHESIA WITH PHENYLEPHRINE AND EPHEDRINE IN CAESAREAN SECTION. Vietnam Journal of Community Medicine, 64(5). https://doi.org/10.52163/yhc.v64i5.768

12. EFFICIENCY TREATMENT OF HYPOTENSION AFTER SPINAL ANESTHESIA WITH PHENYLEPHRINE AND EPHEDRINE IN CAESAREAN SECTION

Bui Dang Minh Tri1, Khuu Van Ut2, Le Thi Ngoc Tuyet3
1 University of Medicine Pham Ngoc Thach
2 Medical Center of Giong Rieng District, Kien Giang Province
3 University of Medicine and Pharmacy at HCMC

Main Article Content

Abstract

Objectives: To compare the results of treatment of hypotension after spinal anesthesia between Phenylephrine and Ephedrine in women undergoing cesarean section.


Subjects and methods: A prospective, controlled study on 63 women with indications for elective cesarean section under spinal anesthesia treated with Phenylephrine or Ephedrine at Giong Rieng District Health Center from January 2022 to September 2022.


Results: After spinal anesthesia, blood pressure tended to decrease. After taking vasopressors, blood pressure increase was not different between the two groups. Following administration of Phenylephrine resulted in a sharper decrease in heart rate to approximately approximating baseline heart rate, while Ephrine did not alter heart rate significantly and was more stable. Cardiac output was significantly reduced in the phenylephrine group and increased in the ephedrine group. Phenylephrine caused more bradycardia than Ephedrine. Phenylephrine causes nausea and vomiting less than Ephedrine. Phenylephrine caused bradycardia more than Ephedrine, Phenylephrine caused nausea, vomiting less than Ephedrine.


Conclusion: Phenylephrine had a strong reduction in heart rate. Ephrine did not change heart rate significantly. Cardiac output decreased in the phenylephrine group and increased in the ephedrine group.

Article Details

Keywords

Ephedrine, Phenylephrine, spinal anesthesia, pregnant women.

References

[1] SM Kinsella, B Carvalho, RA Dyer et al.,
International consensus statement on the
management of hypotension with vasopressors
during caesarean section under spinal
anaesthesia. Obstetric Anesthesia Digest, 38(4):
171-172, 2018.
[2] S Saravanan, M Kocarev, RC Wilson et al.,
Equivalent dose of Ephedrine and Phenylephrine
in the prevention of post-spinal hypotension in
Caesarean section. British journal of anaesthesia,
96(1): 95-99, 2006.
[3] Seppo A, Juha R, Pentti J et al., Ephedrine
and Phenylephrine for avoiding maternal
hypotension due to spinal anaesthesia for
caesarean section: effects on uteroplacental and
fetal haemodynamics1(3): 129-134, 1992.
[4] DG Thomas, SC Robson, N Redfern et al.,
Randomized trial of bolus phenylephrine or
Ephedrine for maintenance of arterial pressure
during spinal anaesthesia for Caesarean section
76(1): 61-65, 1996.
[5] Robert AD, Anthony RR, Dominique VD
et al., Hemodynamic effects of Ephedrine,
Phenylephrine, and the coadministration of
Phenylephrine with oxytocin during spinal97
anesthesia for elective cesarean delivery.
The Journal of the American Society of
Anesthesiologists, 111(4): 753-765, 2009.
[6] P. A. Hall, A. Bennett, M. P. Wilkes et al., Spinal
anaesthesia for caesarean section: comparison of
infusions of Phenylephrine and Ephedrine. Br J
Anaesth, 73(4): 471-4, 1994.
[7] D. G. Thomas, S. C. Robson, N. Redfern et al.,
Randomized trial of bolus phenylephrine or
Ephedrine for maintenance of arterial pressure
during spinal anaesthesia for Caesarean section.
Br J Anaesth, 76(1): 61-5, 1996.
[8] Gregory AL, Richard LK, Jennifer G et al.,
The use of metoprolol and glycopyrrolate to
prevent hypotensive/bradycardic events during
shoulder arthroscopy in the sitting position under
interscalene block 87(6): 1320-1325, 1998.