CLINICAL AND LABORATORY CHARACTERISTICS OF PREECLAMPSIA IN PREGNANT WOMEN WITH UNDERLYING MEDICAL CONDITIONS AT THE NATIONAL HOSPITAL OF OBSTETRICS AND GYNECOLOGY FROM 2023 TO 2025
Main Article Content
Abstract
Objective: To describe the clinical and laboratory characteristics of preeclampsia in pregnant women with underlying medical conditions.
Methods: A cross-sectional descriptive study was conducted on 205 eligible participants at National Hospital of Obstetrics and Gynecology from January 2023 to December 2025.
Results: The mean maternal age was 33.86 ± 5.86 years. Severe preeclampsia accounted for the majority of cases (80.98%). Statistically significant differences were observed between the severe preeclampsia group and the non-severe group regarding urea, AST, ALT, LDH, MHVC, and fetal birth weight. Hypertension was the most common underlying comorbidity and was significantly associated with preeclampsia (OR = 3.12; p < 0.05).
Conclusion: Severe preeclampsia accounted for a high proportion of cases. Hypertension was the most common chronic comorbidity and may contribute to the increased risk and severity of preeclampsia, along with other underlying medical conditions.
Article Details
Keywords
Preeclampsia, underlying medical conditions, clinical characteristics, laboratory findings.
References
[1] Vera-Ponce V.J, Loayza-Castro J.A et al. Global prevalence of preeclampsia, eclampsia, and HELLP syndrome: a systematic review and meta-analysis. Front Reprod Health, 2025, 7. doi: 10.3389/frph.2025.1706009
[2] Who is at risk of preeclampsia? Eunice Kennedy Shriver National Institute of Child Health and Human Development. June 14, 2022. Accessed April 27, 2026. https://www.nichd.nih.gov/health/topics/preeclampsia/conditioninfo/risk
[3] Seely E.W, Ecker J. Chronic hypertension in pregnancy. Circulation, 2014, 129 (11): 1254-1261. doi: 10.1161/CIRCULATIONAHA.113.003904
[4] Do N.C, Vestgaard M et al. Prediction and prevention of preeclampsia in women with preexisting diabetes: the role of home blood pressure, physical activity, and aspirin. Front Endocrinol (Lausanne), 2023, 14: 1166884. doi: 10.3389/fendo.2023.1166884
[5] Wind M, Fierro J.J et al. Pregnancy outcome predictors in systemic Lupus erythematosus: a systematic review and meta-analysis. The Lancet Rheumatology, 2024, 6 (10): e667-e683. doi: 10.1016/S2665-9913(24)00160-7
[6] Tan Z, Ding M et al. Causal pathways in preeclampsia: a Mendelian randomization study in European populations. Front Endocrinol, 2024, 15: 1453277. doi: 10.3389/fendo.2024.1453277
[7] Mai Trọng Hưng, Đỗ Tuấn Đạt và cộng sự. Đặc điểm lâm sàng, cận lâm sàng và những yếu tố liên quan của tiền sản giật ở các thai phụ tại Bệnh viện Phụ Sản Hà Nội năm 2024. Tạp chí Y học Việt Nam, 2025, 554 (3): 225-230. doi: 10.51298/vmj.v554i3.15807
[8] Chung Thị Mỹ Nhung, Trần Quang Hiển, Lâm Đức Tâm. Đặc điểm lâm sàng, cận lâm sàng và kết quả xử trí sản khoa ở thai phụ tiền sản giật tại Bệnh viện Đa khoa Sa Đéc. Tạp chí Y học Việt Nam, 2024, 539 (2): 47-51. doi: 10.51298/vmj.v539i2.9792
[9] Yang Y, Xie Y et al. Characteristics and fetal outcomes of pregnant women with hypertensive disorders in China: a 9-year national hospital-based cohort study. BMC Pregnancy Childbirth, 2022, 22 (1): 924. doi: 10.1186/s12884-022-05260-3
[10] Nguyễn Thị Thu Hà, Đỗ Tuấn Đạt, Phan Thị Huyền Thương. Đặc điểm lâm sàng và cận lâm sàng của thai phụ có dấu hiệu nặng tại Bệnh viện Phụ Sản Hà Nội. Tạp chí Y học Việt Nam, 2024, 538 (1): 42-47. doi: 10.51298/vmj.v538i1.9315