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Published: 2026-07-26
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Tập 67 No 7
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Articles
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Huệ, P. T. K., & Anh, N. T. (2026). EFFECTIVENESS OF MUSCLE RELAXATION WITH LOW-DOSE SUGAMMADEX COMBINED WITH NEOSTIGMINE IN PATIENTS UNDERGOING ABDOMINAL SURGERY WITH ENDOTRACHEAL ANESTHESIA AT THE ANESTHESIA AND RESUSCITATION DEPARTMENT, THANH NHAN HOSPITAL. Vietnam Journal of Community Medicine, 67(7). Retrieved from https://tapchiyhcd.vn/index.php/yhcd/article/view/5939

EFFECTIVENESS OF MUSCLE RELAXATION WITH LOW-DOSE SUGAMMADEX COMBINED WITH NEOSTIGMINE IN PATIENTS UNDERGOING ABDOMINAL SURGERY WITH ENDOTRACHEAL ANESTHESIA AT THE ANESTHESIA AND RESUSCITATION DEPARTMENT, THANH NHAN HOSPITAL

Phan Thi KIm Hue1, Nguyen Tuan ANh2
1 Department of Anesthesiology and Resuscitation, Thanh Nhan Hospital
2 Department of Intensive Care, National Geriatric Hospital

Main Article Content

Abstract

Objective: Residual muscle relaxation (RS) is a common postoperative complication affecting patient safety. This study aims to evaluate the results of reversal of neuromuscular blockade after abdominal surgery using low-dose sugammadex combined with neostigmine at the Anesthesia and Resuscitation Department, Thanh Nhan Hospital. Methods: A descriptive cross-sectional study with longitudinal follow-up of responses in patients undergoing abdominal surgery under endotracheal anesthesia and receiving rheostatectomy with low-dose sugammadex combined with neostigmine at the Anesthesia and Resuscitation Department, Thanh Nhan Hospital from May 2025 to September 2025. Results: The study was conducted on 30 patients who underwent endotracheal anesthesia and muscle relaxation reversal with low-dose sugammadex combined with neostigmine. The proportion of females was almost twice as high as that of males, with an average age of 51.07 ± 9.7 years and an average BMI of 22 ± 1.57 kg/m2. The main surgeries were uterine fibroid and colorectal tumor removal, accounting for 33.3%, with an average duration of 119 ± 35 minutes. The TOF score improved at each time point in the study, with: 46.6% of patients achieving a TOF > 0.7 after 2 minutes, 96.7% achieving a TOF > 70% after 4 minutes, and 100% achieving a TOF > 0.7 after 8 minutes. Similarly, for TOF > 0.9, 66.7% of patients achieved a TOF > 0.9 after 4 minutes, 96.7% achieved a TOF > 0.9 after 6 minutes, and 100% achieved a TOF > 0.9 after 12 minutes. Regarding extubation, 50% of patients in the group had their endotracheal tubes removed after 7 minutes, 86.7% after 9 minutes, and 100% after 16 minutes. Conclusion: The combination of Sugammdex 1 mg/kg with Neostigmine 20 µg/kg and atropine 15 µg/kg showed relatively good muscle relaxant efficacy, with a relatively short time to achieve TOF > 90%.

Article Details

Keywords

Muscle relaxant, low-dose sugammadex, endotracheal anesthesia.

References

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