INVESTIGATING DEPRESSIVE DISORDERS IN PEMPHIGUS PATIENTS UNDERGOING GLUCOCORTICOSTEROID TREATMENT AT HO CHI MINH CITY HOSPITAL OF DERMATO-VENEREOLOGY
Main Article Content
Abstract
Objective: To investigate the prevalence of depression among Pemphigus patients undergoing Glucocorticosteroids treatment at the clinical departments of Ho Chi Minh city Hospital of Dermato-Venereology.
Methods: A cross-sectional study was conducted on 140 patients with clinically and histologically confirmed Pemphigus.
Results: Among the 140 patients, 109 were diagnosed with Pemphigus vulgaris and 31 with Pemphigus foliaceus. Female patients predominated (61.4%). Most patients had mild to moderate disease severity according to the PDAI score (65% and 33.6%, respectively). A relatively high prevalence of depression was observed (43.6%), with the majority classified as mild depression (38.6%). No patients were diagnosed with severe depression.
Conclusion: Comprehensive dermatological management may contribute to reducing the severity of depression in patients with Pemphigus.
Article Details
Keywords
Pemphigus vulgaris, Pemphigus foliaceus, depression.
References
[2] Wohl Y, Mashiah J, Kutz A, Hadj-Rabia S, Cohen A.D. Pemphigus and depression comorbidity: a case control study. Eur J Dermatol, 2015, 25 (6): 602-5. doi: 10.1684/ejd.2015.2649.
[3] Le T.V.T, Nguyen D.Q, Tran N.D, Trinh H.K.T. Association of singlenucleotide NR3C1 gene polymorphisms with glucocorticosteroid responsiveness in patients with Pemphigus vulgaris. Dermatology Reports, 2021, 14 (2): 9190. doi: 0.4081/dr.2021.9190
[4] Drenovska K, Ivanova M, Vassileva S, Shahid M.A, Naumova E. Association of specific HLA alleles and haplotypes with Pemphigus vulgaris in the Bulgarian population. Frontiers in Immunology, 2022, 13: 901386. doi: 10.3389/fimmu.2022.901386.
[5] Sarig O, Bercovici S, Zoller L, Goldberg I, Indelman M, Nahum S et al. Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and Pemphigus vulgaris. Journal of Investigative Dermatology, 2012, 132 (7): 1798-805. doi: 10.1038/jid.2012.46
[6] Kronzer V.L, Bridges S.L, Davis J.M. Why women have more autoimmune diseases than men: an evolutionary perspective. Evol Appl, 2021, 14 (3): 629-33. doi: 10.1111/eva.13167
[7] Paradisi A, Sampogna F, Di Pietro C, Cianchini G, Didona B, Ferri R et al. Quality-of-life assessment in patients with Pemphigus using a minimum set of evaluation tools. J Am Acad Dermatol, 2009, 60 (2): 261-9. doi: 10.1016/j.jaad.2008.09.014.
[8] Hsu Y.M, Fang H.Y, Lin C.L, Shieh S.H. The risk of depression in patients with pemphigus: a nationwide cohort study in Taiwan. Int J Environ Res Public Health, 2020, 17 (6). doi: 10.3390/ijerph17061983
[9] Dipankar De, Kumar S, Handa S, Mahajan R, Singh S.M. Psychological morbidity in Pemphigus patients in clinical remission and its relation with clinico-demographic parameters. J Dtsch Dermatol Ges, 2022, 20 (1): 26-33. doi: 10.1111/ddg.14605.
[10] Metwally D, Fawzy M, ElKalioby M, Hegazy R, Hay R.A, Abd-Elreheem H et al. Assessment of the quality of life, prevalence of depression, and the level of interleukin 6 in patients with Pemphigus vulgaris. Acta Dermatovenerol Croat, 2020, 28 (2): 57-62.