EVALUATION OF BISPECTRAL INDEX GUIDED TARGET-CONTROLLED INFUSION PROPOFOL ANESTHESIA IN PATIENTS RECEIVING HIGH-FLOW NASAL OXYGEN DURING APNEA FOR ENDOSCOPIC VOCAL CORD SURGERY
Main Article Content
Abstract
Objective: To evaluate the effectiveness and safety of bispectral index (BIS)–guided target-controlled infusion (TCI) propofol anesthesia in patients receiving high-flow nasal oxygen during apnea in endoscopic vocal cord surgery. Methods: A prospective descriptive study was conducted on 130 patients undergoing endoscopic vocal cord surgery at 108 Military Central Hospital from October 2022 to December 2025. General anesthesia was induced and maintained using TCI propofol combined with rocuronium for neuromuscular blockade. BIS values, hemodynamic and respiratory parameters, recovery time, and adverse events were recorded and analyzed. Results: The mean duration of anesthesia was 30.06 ± 2.03 minutes, and the mean total propofol dose was 330.9 ± 18.2 mg. The mean recovery time was 4.80 ± 1.20 minutes. Hemodynamic parameters and oxygen saturation remained stable throughout the procedure. No serious respiratory or cardiovascular adverse events were observed. Conclusion: BIS-guided TCI propofol anesthesia combined with high-flow nasal oxygen during apnea is effective and providing rapid recovery. No serious adverse events on respiration and circulation have been recorded.
Article Details
Keywords
Endoscopic vocal cord surgery, high-flow nasal oxygen, propofol, bispectral index.
References
2. Beng Leong, L., N. Wei Ming, and L. Wei Feng, High flow nasal cannula oxygen versus noninvasive ventilation in adult acute respiratory failure: a systematic review of randomized-controlled trials. European Journal of Emergency Medicine, 2019. 26(1): p. 9-18. doi: 10.1097/MEJ.0000000000000557
3. Al-Rifai, Z. and D. Mulvey, Principles of total intravenous anaesthesia: basic pharmacokinetics and model descriptions. BJA Education, 2016. 16(3): p. 92-97.
4. Singh, H., Bispectral index (BIS) monitoring during propofol-induced sedation and anaesthesia. European journal of anaesthesiology, 1999. 16(1): p. 31-36. doi: 10.1046/j.1365-2346.1999.00420.x
5. Gussack, G.S., R.F. Evans, and E.J. Tacchi, Intravenous anesthesia and jet ventilation for laser microlaryngeal surgery. Annals of Otology, Rhinology & Laryngology, 1987. 96(1): p. 29-33. doi: 10.1177/000348948709600107
6. Khan, S.N., et al., Comparison of intubating conditions between induction with target-controlled infusion (TCI) of remifentanil and propofol with or without a topical lignocaine spray in elective surgery for adults. Anaesthesia, Pain & Intensive Care, 2025. 29(2): p. 163-169. doi: 10.35975/apic.v29i2.2699
7. Šafránková, P. and J. Bruthans, Target-Controlled Infusion of Propofol: A Systematic Review of Recent Results. Journal of Medical Systems, 2025. 49(1): p. 1-9. doi: 10.1007/s10916-025-02187-y
8. Wahid, I.U.I., et al., Propofol Target-Controlled Infusion (TCI) vs. Manual-Controlled Infusion (MCI)—Comparable Hemodynamic Stability with Reduced Propofol Consumption: Randomized Clinical Trial. Archives of Anesthesiology and Critical Care, 2025. doi: 10.18502/aacc.v11i5.19929
9. Tạ Đức Luận, Đánh giá hiệu quả vô cảm và tính an toàn của gây mê Propofol kiểm soát nồng độ đích cho nội soi tán sỏi niệu quản ngược dòng ở bệnh nhân ngoại trú. Tap chí Y dược lâm sàng 108, 2015.
10. Hà Thị Kim Tuyến, Nguyễn Ngọc Anh, Hà Ngọc Chi, Đánh giá hiệu quả của BIS trong gây mê kiểm soát nồng độ đích bằng Propofol trên phẫu thuật u tuyến yên qua mũi. Tạp chí Y học TP. Hồ Chí Minh, 2015. 19(1).