EVALUATION OF THE PROTECTIVE EFFECT OF MANNITOL-CONTAINING OPHTHALMIC VISCOSURGICAL DEVICES ON CORNEAL ENDOTHELIAL CELLS DURING PHACOEMULSIFICATION IN PATIENTS WITH LOW ENDOTHELIAL CELL DENSITY
Main Article Content
Abstract
Objective: To evaluate the safety and corneal endothelial protective efficacy of a mannitol-containing ophthalmic viscosurgical device during phacoemulsification for cataract surgery in patients with low corneal endothelial cell density.
Methods: This randomized controlled trial included cataract patients indicated for phacoemulsification with preoperative endothelial cell density ranging from 1000 to 2000 cells/mm² at Saigon Vinh Eye Hospital from October 2024 to May 2025. Patients were randomly assigned to three groups: group A received an ophthalmic viscosurgical device containing 2% sodium hyaluronate combined with 0.5% mannitol; group B received an ophthalmic viscosurgical device containing 1.4% sodium hyaluronate; and group C received an ophthalmic viscosurgical device containing 2.4% hydroxypropyl methylcellulose. Endothelial cell density and morphology, central corneal thickness, and best-corrected visual acuity were assessed preoperatively and at 1 week, 1 month, and 3 months postoperatively.
Results: At 1 week postoperatively, group A demonstrated significantly higher endothelial cell density, lower coefficient of variation, higher percentage of hexagonal cells, and lower central corneal thickness compared with the other two groups (p < 0.05). Postoperative visual acuity improved more markedly in group A. By 1 month, corneal edema had largely resolved in all groups, and intergroup differences in visual acuity were no longer statistically significant.
Conclusions: Ophthalmic viscosurgical device containing sodium hyaluronate 2% and mannitol 0.5% provides superior corneal endothelial protection during phacoemulsification in patients with low preoperative endothelial cell density, contributing to reduced postoperative corneal edema and faster early visual recovery postoperatively
Article Details
Keywords
Cataract, intraocular mucus, mannitol.
References
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