CLINICAL CHARACTERISTICS AND ANTIBIOTIC RESISTANCE PHENOTYPES OF KLEBSIELLA PNEUMONIAE ISOLATED AT XUYEN A GENERAL HOSPITAL IN 2025
Main Article Content
Abstract
Objectives: To investigate the clinical characteristics and antibiotic resistance phenotypes of Klebsiella pneumoniae isolated at Xuyen A General Hospital, Ho Chi Minh city, period January-June 2025.
Methods: A cross-sectional descriptive study was conducted on 50 non-duplicate K.pneumoniae isolates from clinical specimens. Identification was performed using biochemical methods on the VITEK 2 Compact system, with molecular confirmation by real-time PCR using the ZKIR primer pair. Antimicrobial susceptibility testing was performed by automated broth microdilution and interpreted according to CLSI M100 Ed.35 (2025).
Results: The mean patient age was 62.7 ± 12.6 years, with equal sex distribution. The most common comorbidities were hypertension (58%) and diabetes mellitus (54%). Urine was the predominant specimen type (44%), and 86% of isolates were community-acquired. All isolates (100%) were resistant to Ampicillin. Carbapenem resistance was detected in 48% of isolates; multidrug resistance (MDR) in 68%; extensive drug resistance (XDR) in 54%; and ESBL production in 18%. Gentamicin was the only antibiotic retaining a high susceptibility rate (74%).
Conclusion: K.pneumoniae isolates at Xuyen A General Hospital showed alarming rates of Carbapenem resistance and multidrug resistance. These findings provide the first local microbiological data to support empirical antibiotic therapy at this institution.
Article Details
Keywords
Klebsiella pneumoniae, Carbapenem resistance, multidrug resistance, resistance phenotype.
References
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