COMPARISON OF THE DISCRIMINATIVE PERFORMANCE OF FRAX AND GARVAN MODELS FOR ASSESSING FRACTURE RISK IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES MELLITUS
Main Article Content
Abstract
Objectives: To investigate the prevalence of osteoporotic fractures and to compare the discriminative performance of the FRAX and GARVAN models in assessing fracture risk among postmenopausal women with type 2 diabetes mellitus in Vietnam.
Methods: A descriptive cross-sectional study was conducted in 94 postmenopausal women with type 2 diabetes mellitus who attended the Departments of Endocrinology, Musculoskeletal, and Orthopedic Trauma at Nguyen Tri Phuong Hospital between August 2025 and January 2026.
Results: The median age of the study population was 71 [68-75]. The prevalence of current osteoporotic fractures was 22.3%. Osteoporosis was identified in 89.1% of participants, with 53.2% at the lumbar spine and 63.8% at the femoral neck. The area under the receiver operating characteristic curve (AUC) of the GARVAN model was higher than that of the FRAX model for both 10-year major osteoporotic fracture risk (0.789 vs. 0.742) and 10-year hip fracture risk (0.759 vs. 0.713); however, these differences were not statistically significant (DeLong test, p > 0.05).
Conclusions: Postmenopausal women with type 2 diabetes mellitus exhibited a relatively high prevalence of osteoporotic fractures. Both the FRAX and GARVAN models demonstrated comparable discriminative performance and were able to identify individuals with current fractures in this study population.
Article Details
Keywords
Osteoporotic fracture, type 2 diabetes mellitus, postmenopausal women, FRAX, GARVAN.
References
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