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Published: 2026-04-01
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DOI: https://doi.org/10.52163/yhc.v67iCD3.4731
Issue
Tập 67 Số CĐ3-NCKH
Section
Articles
How to Cite
Nguyệt, N. N., Hiếu, C. C., Hằng, V. T., Khánh, B. V., Tú, Đinh T. D., Lâm, Đỗ T. T., Anh, N. N., Thương, N. T. H., & Linh, N. T. (2026). CHARACTERISTICS OF ANTIBIOTIC SKIN TESTS IN PATIENTS WITH A HISTORY OF ALLERGIES AT THE CLINICAL ALLERGY AND IMMUNOLOGY CENTER, BACH MAI HOSPITAL. Vietnam Journal of Community Medicine, 67(CD3). https://doi.org/10.52163/yhc.v67iCD3.4731

CHARACTERISTICS OF ANTIBIOTIC SKIN TESTS IN PATIENTS WITH A HISTORY OF ALLERGIES AT THE CLINICAL ALLERGY AND IMMUNOLOGY CENTER, BACH MAI HOSPITAL

Nguyen Nhu Nguyet1, Chu Chi Hieu1, Vu Thi Hang1, Bui Van Khanh1, Dinh Thi Dieu Tu2, Do Thi Tung Lam3, Nguyen Ngoc Anh4, Nguyen Thi Huyen Thuong4, Nguyen Thuy Linh4
1 Allergy Center – MDLS, Bach Mai Hospital
2 General Planning Department, Bach Mai Hospital
3 Tam Anh Hospital
4 Hanoi Medical University

Main Article Content

Abstract

Objective: To describe the characteristics of antibiotic skin testing in patients with a history of allergy.


Methods: A prospective, cross-sectional descriptive study was conducted in patients with a history of allergy who attended the Allergen Clinic of the Center for Allergy and Clinical Immunology from January to March 2025.


Results: The study included 872 patients who underwent a total of 5,195 skin tests, comprising 4,875 skin prick tests (93.8%) and 320 intradermal tests (6.2%). Only 55 patients had positive skin test results to at least one antibiotic (44 skin prick tests and 11 intradermal tests). The highest rate of positive skin tests was observed in the quinolone group, whereas penicillins, carbapenems, tetracyclines, and lincosamides showed the lowest positivity rates. No cross-reactivity between antibiotics was detected.


Conclusion: Most antibiotic skin tests in patients with a history of allergy were negative; therefore, a general history of allergy may not be a risk factor for IgE-mediated antibiotic allergy.

Article Details

Keywords

allergy, skin prick test, intradermal test, antibiotic

References

[1] Blumenthal, K. G., Peter, J. G., Trubiano, J. A., & Phillips, E. J., "Antibiotic allergy," The Lancet, vol. 393(10167), pp. 183-198, 2019.
[2] Demoly, P., Adkinson, N. F., Brockow, K., Castells, M., Chiriac, A. M., Greenberger, P. A., et al., "International consensus on drug allergy," Allergy, vol. 69(4), pp. 420-437, 2014.
[3] Macy, E., "Penicillin and beta-lactam allergy: Epidemiology and diagnosis," Current Allergy and Asthma Reports, Vols. 14(11), Article 476, 2014.
[4] Torres, M. J., Adkinson, N. F., Caubet, J. C., Khan, D. A., Kidon, M. I., Mendelson, L., et al., "Controversies in drug allergy: Beta-lactam hypersensitivity testing," Journal of Allergy and Clinical Immunology: In Practice, vol. 7(1), pp. 40-45, 2019.
[5] Khan, D. A., Banerji, A., Blumenthal, K. G., Phillips, E. J., & Solensky, R., "Drug allergy: A 2022 practice parameter update," Journal of Allergy and Clinical Immunology, vol. 150(6), pp. 1333-1393, 2022.
[6] Macy, E., & Ngor, E. W, "Safely diagnosing clinically significant penicillin allergy using only penicillin skin testing and oral amoxicillin challenge," Journal of Allergy and Clinical Immunology: In Practice, vol. 1(3), pp. 258-263, 2013.
[7] Jourdan A et al, "Antibiotic hypersensitivity and adverse reactions: management and implications in clinical practice," Allergy Asthma Clin Immunol, p. 16:6, 2020.