SO SÁNH KẾT QUẢ ĐIỀU TRỊ BỆNH TRỨNG CÁ ĐỎ THỂ NHẸ VÀ VỪA BẰNG BÔI ACID AZELAIC 10% SO VỚI METRONIDAZOLE 1%

Abstract

Objectives: To compare the results of treatment of mild and moderate rosacea with Azelaic acid
10% Metronidazole 1%.
Methods: A randomized controlled intervention study on 60 patients, 30 of whom used Azlaic 10%
and 30 of whom metronidazole 1%.
Results: In the Azelaic group, the mean CEAS score before treatment was 9.1±3.0, after 12 weeks
of treatment it decreased to 0.3±0.4. In the Metronidazole group, the mean CEAS score before
treatment was 9.1±3.4, after 12 weeks of treatment it decreased to 1.6±0.5. In the Azelaic group, the
mean IGAS score before treatment was 2.2 ± 0.7, after 12 weeks of treatment it decreased to 0.07 ±
0.3. The mean IGAS score in the metronidazole group before treatment was 2.1±0.7, after 12 weeks
of treatment it decreased to 0.1±0.3. Before treatment, the GFSS score for assessing hot flushes was
equal between the Azelaic and Metronidazole groups, 0.7 ± 0.7. After 12 weeks of treatment, patients
in both groups were symptom free. In the Azelaic group, there were 81.2% of patients with itching
and 60% of patients with stinging. This condition was less common in the Metronidazole group with
57.1% of patients with itching and 55.6% of patients with stinging.
Conclusions: Azelaic 10% and Metronidazole 1% have both been shown to be effective in treating
rosacea, although Azelaic has been shown to be slightly more effective. In contrast, the frequency of
mild itching and stinging reactions was more common in the Azelaic group.