BIOACTIVE COMPOUNDS AND POTENTIAL MEDICAL APPLICATIONS OF SEAHORSES (HIPPOCAMPUS SPP.): A NARRATIVE REVIEW
Main Article Content
Abstract
Objective: To synthesize major bioactive compound groups and preclinical evidence on medical application–related effects of seahorses (Hippocampus spp.).
Methods: A structured narrative review was conducted by searching PubMed, Web of Science, Scopus, Google Scholar, and CNKI up to 30/11/2025.
Results: Seahorses are rich in proteins/amino acids and contain peptides, glycoproteins, sterols, unsaturated fatty acids, and trace elements. In vitro and in vivo studies indicate antioxidant activity; improved endurance indices and post-exertion fatigue-related markers; improved sperm parameters and testosterone in rat models of reproductive impairment; and limited signals for anti-inflammatory/immunomodulatory effects, neuroprotection, and UV-related anti-photoaging effects. Safety data remain limited, with concerns regarding quality variability and environmental contaminants; moreover, many species are listed in CITES Appendix II, underscoring the need for legal supply chains and sustainable aquaculture.
Conclusion: No human clinical trials were identified; therefore, current evidence is insufficient to recommend therapeutic use. Future work should prioritize product standardization, toxicity–interaction assessment, and well-designed controlled clinical trials.
Article Details
Keywords
Hippocampus; peptides; antioxidant; anti-fatigue; safety; conservation.
References
[2] Cui X, Zhao X, Zhang H, et al. Advances in the global distribution, chemical constituents and pharmacology of Hippocampus, a traditional marine Chinese medicine. Front Mar Sci. 2021;8:774927.
[3] Zhang Z, Zhang L, Chen L, et al. Chemical constituents, pharmacological activities and quality evaluation methods of genus Hippocampus: a comprehensive review. Chin J Nat Med. 2023;21(8):1–18.
[4] Sanaye SV, Tishel R, Ingole B, et al. Evaluation of antioxidant activities in captive-bred cultured seahorse Hippocampus kuda (Bleeker, 1852). Aquaculture. 2014;434:100–107.
[5] Salam MR, Hossain MS, Ahmed GU, et al. Morphological, molecular identification and evaluation of antioxidant activities of seahorse Hippocampus hippocampus extracts. J King Saud Univ Sci. 2023;35(3):102654.
[6] Guo Z, Lin D, Guo J, Zhang Y, Zheng B. In vitro antioxidant activity and in vivo anti-fatigue effect of seahorse (Hippocampus) peptides. Molecules. 2017;22(3):482.
[7] Kang N, Lee H, Seo YK, et al. Anti-fatigue activity of a mixture of seahorse (Hippocampus abdominalis) hydrolysate and red ginseng. Fish Aquat Sci. 2017;20:3.
[8] Mundijo T, Isnansetyo A, Wullur S, et al. Characterization of seahorse (Hippocampus comes L.) extracts: proximate composition, amino acids and bioactive compounds. J Adv Vet Anim Res. 2022;9(4):610–616.
[9] Mundijo T, Sugiharto S, Cahyono B, et al. The seahorse (Hippocampus comes L.) extract ameliorates sperm qualities, testosterone level and serum biochemistry in rats induced by depo medroxyprogesterone acetate. Vet World. 2023;16(4):890–898.
[10] Yang F, Zhang Y, Li Y, et al. Anti-photoaging effects of an antioxidant peptide from seahorse (Hippocampus abdominalis) alcalase hydrolysate. Mar Drugs. 2024;22(5):275.