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Published: 2026-03-02
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DOI: https://doi.org/10.52163/yhc.v67i2.4406
Issue
Vol. 67 No. 2
Section
Articles
How to Cite
Lương, N. T. H., Hòa, L. T., Trung, T. Q., Linh, L. T., & Âu, H. Đình. (2026). CHARACTERISTICS OF THE PENUMBRA AND HYPOPERFUSED LESIONS ON ARTERIAL SPIN LABELING PERFUSION SEQUENCES ACCORDING TO LARGE VESSEL OCCLUSION SITES IN ACUTE ISCHEMIC STROKE. Vietnam Journal of Community Medicine, 67(2). https://doi.org/10.52163/yhc.v67i2.4406

CHARACTERISTICS OF THE PENUMBRA AND HYPOPERFUSED LESIONS ON ARTERIAL SPIN LABELING PERFUSION SEQUENCES ACCORDING TO LARGE VESSEL OCCLUSION SITES IN ACUTE ISCHEMIC STROKE

Nguyen Thi Hong Luong1, Le Thi Hoa1, Tran Quang Trung2, Le Tuan Linh2,3, Hoang Dinh Au1,2
1 Central Geriatric Hospital
2 Hanoi Medical University Hospital
3 Hanoi Medical University

Main Article Content

Abstract

Objective: this study aims to describe arterial spin labeling (ASL) perfusion characteristics in acute ischemic stroke due to large vessel occlusion, according to the site of vascular obstruction.


Subjects and Methods: We conducted a cross-sectional study on 55 patients with LVO who underwent emergency MRI including DWI, TOF-MRA, and ASL. Infarct core volume, penumbra volume, and ASL hypoperfused volume were compared across vascular occlusion sites using the Kruskal–Wallis test. Ratios of penumbra-to-core and ASL-to-core volumes were calculated to assess the extent of perfusion mismatch.


Results: Infarct core volumes did not differ significantly among occlusion sites (p = 0.453). In contrast, penumbra volumes differed significantly, being largest in ICA and ICA+MCA occlusions and smallest in MCA occlusions (p = 0.030). ASL hypoperfused volume showed a borderline difference (p = 0.052). Both penumbra/core and ASL/core ratios differed significantly (p = 0.018 and 0.021), indicating greater perfusion mismatch in proximal occlusions compared with MCA occlusions.


Conclusion: ASL effectively distinguishes perfusion abnormalities according to the site of vascular occlusion. ASL is a valuable non-contrast technique for identifying hypoperfused but salvageable tissue in acute stroke.

Article Details

Keywords

MRI, Arterial spin labeling, Acute ischemic stroke, large vessel occlusion

References

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