RESULTS OF RETROGRADE TRANSURETHRAL HOLMIUM LASER ENUCLEATION OF THE PROSTATE FOR BENIGN PROSTATIC HYPERPLASIA AT VINMEC TIMES CITY INTERNATIONAL GENERAL HOSPITAL

Vu Ngoc Thang1, Nguyen Manh Ha2, Tran Duc Quy2, Vu Viet Duc2
1 The University of Medicine and Pharmacy Hospital (Linh Dam facility), University of Medicine and Pharmacy, Vietnam National University, Hanoi
2 University of Medicine and Pharmacy, Thai Nguyen University

Main Article Content

Abstract

Objectives: To evaluate the outcomes of retrograde transurethral enucleation of the benign prostatic hyperplasia using Holmium laser at Vinmec Times City International General Hospital.


Materials and methods: A cross-sectional descriptive study was conducted on 64 patients diagnosed with benign prostatic hyperplasia who underwent Holmium laser surgery at Vinmec Times City International General Hospital from February 2022 to June 2025.


Results: The mean age of 64 patients was 69.7 ± 9.33 years; average BMI was 22.0 ± 2.04 kg/m²; mean prostate volume was 68.5 ± 41.21 ml; mean prostate-specific antigen was 5.37 ± 4.08 ng/ml. Comorbidities were present in 34.4% of patients; no intraoperative complications were recorded. Mean enucleation time was 70.78 ± 22.01 minutes; morcellation time was 25.39 ± 7.73 minutes; total operative time was 96.17 ± 28.37 minutes. Bladder irrigation duration averaged 41.78 ± 20.08 hours; catheterization time was 62.30 ± 28.11 hours; postoperative hospital stay was 4.08 ± 3.29 days. IPSS decreased from 21.4 ± 3.4 preoperatively to 5.98 ± 2.30 at 1 month, 5.20 ± 1.71 at 3 months, and 4.38 ± 1.64 at 6 months (p < 0.05). Maximum urinary flow rate improved from 4.86 ± 3.78 ml/s pre-op to 16.13 ± 2.92 ml/s at 1 month, 18.72 ± 3.69 ml/s at 3 months, and 20.33 ± 4.11 ml/s at 6 months (p < 0.05). Quality of life scores improved from 4.59 ± 0.68 to 1.98 ± 0.77 at 1 month and 1.75 ± 0.67 at 6 months (p < 0.05). No Clavien-Dindo complications grade ≥ III were observed; 73.4% of patients achieved Qmax > 15 ml/s at 3 months; 89.1% had no urinary incontinence; 67.2% met the Trifecta criteria.


Conclusion: Retrograde transurethral Holmium laser enucleation of the prostate is a safe and effective treatment for benign prostatic hyperplasia at Vinmec Times City International General Hospital, significantly improving lower urinary tract symptoms, increasing urinary flow, enhancing quality of life, shortening hospital stay, with low complication rates, and achieving the Trifecta standard.

Article Details

References

[1] Chen X, Yang S et al. Comprehensive analysis of the global, regional, and national burden of benign prostatic hyperplasia from 1990 to 2021. Sci Rep, 2025, 15: 5644. https://doi.org/10.1038/s41598-025-90229-3.
[2] Daryanto B, Suryanullah W.S et al. Holmium laser enucleation of the prostate versus transurethral resection of the prostate in treatment of benign prostatic hyperplasia: A meta-analysis of 13 randomized control trials. Curr Urol, 2025, 19: 6-16. https://doi.org/10.1097/CU9.0000000000000257.
[3] Schumacher S, Marghawal D et al. Patient reported outcome and quality of life measured by a simple questionnaire in patients with symptomatic benign prostate hyperplasia treated by holmium laser enucleation of the prostate (HoLEP). Front Surg, 2024, 11: 1358701. doi: 10.3389/fsurg.2024.1358701
[4] Özkaptan O, Sevinç C et al. Comparison of outcome for holmium laser enucleation prostate and rezum system in benign prostate hyperplasia: a matched pair analysis. World J Urol, 2025, 43: 242. https://doi.org/10.1007/s00345-025-05644-y.
[5] Grosso A.A, Di Maida F et al. Patterns and predictors of optimal surgical and functional outcomes after holmium laser enucleation of the prostate (HoLEP): Introducing the concept of Trifecta. World J Mens Health, 2023, 41: 603-11. https://doi.org/10.5534/wjmh.220042.
[6] Giulioni C, Tallè M et al. The implementation of Trifecta score to assess the quality of Holmium laser enucleation of the prostate in elderly patients: An analysis of perioperative and functional outcomes and the impact of age. J Clin Med, 2025, 14: 3410. https://doi.org/10.3390/jcm14103410.
[7] Park J.H, Yoon J et al. Peripheral zone thickness in preoperative MRI is predictive of Trifecta achievement after Holmium laser enucleation of the prostate (HoLEP). Abdom Radiol N Y, 2024, 49: 2358-67. https://doi.org/10.1007/s00261-024-04233-8.