25. ANEMIA IN PEDIATRIC PATIENTS WITH CHRONIC KIDNEY DISEASE STAGES G3A-5: PREVALENCE AND ASSOCIATED FACTORS
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Abstract
Objective: The aim of this study was to determine the prevalence of anemia in pediatric patients with chronic kidney disease (CKD) stages G3a-5 at the Nephrology-Endocrinology Department, Children's Hospital 2 (CH2) in 2025, and to investigate the factors associated with anemia.
Subjects and methods: This cross-sectional study was conducted with 77 pediatric patients diagnosed with CKD stages G3a to G5, aged over 2 years, receiving outpatient or inpatient care at CH2 in 2025. Anemia and nutritional status were classified according to the World Health Organization (WHO) standards. The association between anemia and demographic, disease-related, and nutritional factors was also explored.
Results: The prevalence of anemia in the study population was 77.9%, with 52% of cases exhibiting moderate anemia. Normocytic, normochromic anemia was present in 75% of cases. Approximately 40% of the patients had iron deficiency. Statistical analysis revealed a significant association between anemia and the patient's age group (OR = 1.26; 95% CI: 1.04 – 1.52), disease stage (PR = 1.66; 95% CI: 0.93 – 2.95), treatment method, and chronic malnutrition status (PR = 1.36; 95% CI: 1 – 1.86).
Conclusion: The prevalence of anemia in pediatric patients with CKD stages G3a-5 is high at 77.9%, with more than 50% of cases being classified as moderate anemia, and the majority being normocytic, normochromic. There is a need to enhance collaboration between nephrologists and nutrition specialists in adjusting dietary interventions to more effectively manage anemia in this group of pediatric CKD patients.
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Keywords
chronic kidney disease, anemia, children, diet.
References
[2] Atkinson MA, Furth SL.(2011). Anemia in children with chronic kidney disease. Nat Rev Nephrol;7(11):635-641. doi:10.1038/nrneph.2011.115
[3] Lee KH, Park E, Choi HJ, et al. (2019). Anemia and Iron Deficiency in Children with Chronic Kidney Disease (CKD): Data from the Know-Ped CKD Study. J Clin Med;8(2):152. doi:10.3390/jcm8020152
[4] Huong NTQ, Long TD, Bouissou F, et al. (2009). Chronic kidney disease in children: the National Paediatric Hospital experience in Hanoi, Vietnam. Nephrol Carlton Vic;14(8):722-727. doi:10.1111/j.1440-1797.2009.01142.x
[5] Atkinson MA, Martz K, Warady BA, Neu AM. (2010) Risk for anemia in pediatric chronic kidney disease patients: a report of NAPRTCS. Pediatr Nephrol Berl Ger;25(9):1699-1706. doi:10.1007/s00467-010-1538-6
[6] Wong MMY, Tu C, Li Y, et al. (2020) Anemia and iron deficiency among chronic kidney disease Stages 3–5ND patients in the Chronic Kidney Disease Outcomes and Practice Patterns Study: often unmeasured, variably treated. Clin Kidney J;13(4):613-624. doi:10.1093/ckj/sfz091
[7] van Eck van der Sluijs A, Abrahams AC, Rookmaaker MB, et al. (2021). Bleeding risk of haemodialysis and peritoneal dialysis patients. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc;36(1):170-175. doi:10.1093/ndt/gfaa216