Article Sidebar

PDF (Tiếng Việt)
Published: 2025-10-02
Abstract Views: 0
Views PDF (Tiếng Việt): 0
DOI: https://doi.org/10.52163/yhc.v66iCD16.3327
Issue
Tập 66 Số CĐ16-HNKH Bệnh viện Nhi Đồng 2
Section
Articles
How to Cite
Nhận, V. C., Tùng, T. H. ., Vân, L. P. T., Anh, T. T. H., & Liêm, B. T. (2025). 15. EVALUATION OF ANTIBIOTIC USE AND FACTORS INFLUENCING TREATMENT OUTCOMES IN THE INTENSIVE CARE UNIT, CHILDREN’S HOSPITAL 2 FROM JUNE 2022 TO JUNE 2023. Vietnam Journal of Community Medicine, 66(CD16). https://doi.org/10.52163/yhc.v66iCD16.3327

15. EVALUATION OF ANTIBIOTIC USE AND FACTORS INFLUENCING TREATMENT OUTCOMES IN THE INTENSIVE CARE UNIT, CHILDREN’S HOSPITAL 2 FROM JUNE 2022 TO JUNE 2023

Vo Cong Nhan, Trinh Huu Tung, Le Pham Tuong Van, Trinh Thi Hong Anh, Bui Thanh Liem

Main Article Content

Abstract

Objective: To survey the use of antibiotics and factors associated with treatment outcomes in the Intensive Care Unit (ICU) of the Children’s Hospital 2.


Subjects and Methods: A descriptive cross-sectional, retrospective study on 350 medical records of children hospitalized in ICU from June 2022 to June 2023.


Results: The most used antibiotics were vancomycin (83.4%) and carbapenem (78%). Among 3,103 medical orders evaluated for antibiotic appropriatenes, 7.7% were inappropriate in terms of antibiotic selection, and 5.7% were inappropriate in terms of antibiotic dosage. The overall treatment success rate was 88.6%. Multivariate analysis revealed three factors associated with failure outcomes: septic shock (p = 0.002; OR 4.63; 95%CI 1.78 – 12.1), undergoing renal replacement therapy (p = 0.002; OR 6.53; 95%CI 1.99 – 21.49), and suspected invasive fungal infection (p = 0.002; OR 6.43; 95%CI 1.99 – 20.76) or confirmed invasive fungal infection (p = 0.001; OR 18.62; 95%CI 3.17 - 109.52).


Conclusion: In general, antibiotic prescriptions and dosages were mostly adherent to current guidelines. Factors associated with failure treatment outcomes included septic shock, undergoing renal replacement therapy, and suspected or confirmed invasive fungal infections.

Article Details

Keywords

antibiotic therapy, treatment effectiveness, ICU, pediatric

References

[1] Bộ Y tế. (2015). Hướng dẫn sử dụng kháng sinh. Nhà xuất bản Y học
[2] Bộ Y tế. (2022). Dược thư Quốc gia Việt Nam. Nhà xuất bản Khoa học và Kỹ thuật.
[3] Bệnh viện Nhi Đồng 2 (2019). Hướng dẫn điều trị Nhi khoa 2019. Nhà xuất bản Y học.
[4] Nguyễn Thị Bích Nga (2015). Đánh giá sử dụng kháng sinh hợp lý trên bệnh nhân nhiễm vi khuẩn đa kháng trước và sau can thiệp tại khoa Hồi sức tích cực – chống độc Bệnh viện Nhi Đồng 1 [luận văn thạc sĩ]. Đại học Y Dược TP. Hồ Chí Minh.
[5] Trần Anh (2018). Đặc điểm nhiễm khuẩn bệnh viện tại khoa Hồi sức tích cực và Chống độc Bệnh viện Nhi Đồng 2 năm 2018.
[6] Chiotos K, Tamma PD, Metjian RJ, et al. (2023). Antibiotic indications and appropriateness in the Pediatric Intensive Care Unit: a 10-center point prevalence study. Clin Infect Dis. 2023;76(3): e1021–30.
[7] Tamma PD, Aitken SL, Bonomo RA, et al (2023). Infectious Diseases Society of America 2023 guidance on the treatment of antimicrobial-resistant Gram-negative infections. Clin Infect Dis. 2023; ciad428.
[8] Abbas Q, Nadeem S, Shabbir I, et al. (2016). Evaluation of antibiotic use in Pediatric Intensive Care Unit of a developing country. Indian J Crit Care Med. 2016;20(5):291–4.