27. EFFECTIVENESS OF PROGRAMMED INTERMITTENT EPIDURAL BOLUSES OF ANAROPIN 0.08% DURING EPIDURAL ANESTHESIA ON PAIN RELIEF DURING LABOR AT VINMEC SMART CITY INTERNATIONAL GENERAL HOSPITAL

Ta Quang Hung1, Nguyen Tuan Linh1, Khuong Hai Yen1, Tran Van Tam1, Bui Thi Kim Thanh1, Pham Thi My Duyen1, Tran Cong Dac1, Nguyen Thi Cuc1
1 Vinmec Smart City International General Hospital

Main Article Content

Abstract

Objectives: The objective of this study was to compare the pain relief effectiveness of PIEB using a mixture of Anaropin 0.08% and Fentanyl 1 mcg/ml compared to Anaropin 0.1% and Fentanyl 1 mcg/ml in epidural anesthesia during labor.


Subjects and methods: A randomized clinical trial was used in this study. A simple random sampling method was used to recruit 83 pregnant women and divided them into two groups, group 1 Anaropin 0.1% and Fentanyl 1 mcg/ml and group 2 using Anaropin 0.08% and Fentanyl 1 mcg/ml.


Results: There was almost no difference in VAS scores between the groups using Anaropin 0.1% and Anaropin 0.08%. At the stage of full cervical dilation and the II stage, the VAS score of the group using Anaropin 0.08% was higher than that of the group using Anaropin 0.1%. The satisfaction level of the group using Anaropin 0.08% was higher than that of the group using Anaropin 0.1%.


Conclusion: Anaropin 0.08% had similar pain relief effectiveness but lower drug dosage, lower incidence of adverse effects and higher satisfaction compared to Anaropin 0.1%.

Article Details

References

[1] Labor S, Maguire S, The Pain of Labour. Rev Pain, 2008, 2 (2), p. 15-9.
[2] Lam K.K, Leung M.K.M, Irwin M.G. Labour analgesia: update and literature review. Hong Kong Med J, 2020, 26 (5), p. 413-420.
[3] Ojo O.A et al. Comparison of Programmed Intermittent Epidural Boluses With Continuous Epidural Infusion for the Maintenance of Labor Analgesia: A Randomized, Controlled, Double-Blind Study. Anesth Analg, 2020, 130 (2), p. 426-435.
[4] Barbe A et al. Programmed intermittent epidural boluses (PIEB) in labor analgesia : a narrative review of the present. Acta Anaesth, 2019, 70, p. 11-21.
[5] Trịnh Thị Hằng và cộng sự. So sánh hiệu quả giảm đau của phương pháp truyền thuốc tê liên tục với phương pháp tiêm ngắt quãng tự động các liều thuốc tê khi gây tê ngoài màng cứng giảm đau trong chuyển dạ. Tạp chí Y học Việt Nam, 2022, 518 (1), tr. 186-190.
[6] Đỗ Văn Lợi. Nghiên cứu hiệu quả giảm đau trong chuyển dạ của phương pháp gây tê ngoài màng cứng do và không do bệnh nhân tự điều khiển. Trường Đại học Y Hà Nội, 2017.
[7] Michel Levy J.M. Pharmacokinetics and Pharmacodynamics of Local Anesthetics, in Topics in Local Anesthetics, V.M. Whizar-Lugo and E. Hernández-Cortez, Editors. 2020, IntechOpen: Rijeka.
[8] Riley E.T, Carvalho B., Programmed Intermittent Epidural Boluses (PIEB) for Maintenance of Labor Analgesia: A Superior Technique to Continuous Epidural Infusion? Turk J Anaesthesiol Reanim, 2017, 45 (2), p. 65-66.
[9] Vinyes D, Muñoz-Sellart M, Fischer L. Therapeutic Use of Low-Dose Local Anesthetics in Pain, Inflammation, and Other Clinical Conditions: A Systematic Scoping Review. J Clin Med, 2023, 12 (23).